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- W2003193650 abstract "Moisture sorption characteristics and the role of moisture on the compression properties of direct compression anhydrous lactose was investigated. Anhydrous lactose sorbed little moisture even when exposed to very high relative humidities. The equilibrium moisture content of the diluent was less than 1% at 55% relative humidity, 1.66% at 80% relative humidity and 2.03% at 92% relative humidity. An increase in moisture content of lactose resulted in a reduction in hardness of the tablets and increased pressure requirements to achieve specified hardness values. Heckel plots obtained from the compression data of the diluent were linear for all moisture contents. Yield pressures calculated from the Heckel plots increased at moisture contents greater than that of the original diluent. Differential scanning calorimetry performed on the diluent with 5.13% moisture showed that the added water was bound as the crystalline hydrate." @default.
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- W2003193650 title "Effect of Moisture Content on Compression Properties of Directly Compressible High Beta-Content Anhydrous Lactose" @default.
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- W2003193650 doi "https://doi.org/10.3109/03639049109048533" @default.
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