FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003193691> ?p ?o ?g. }

• W2003193691 endingPage "362" @default.
• W2003193691 startingPage "354" @default.
• W2003193691 abstract "Two newly described quaternary heterocyclylamino β-lactams, L-642, 946 and L-652, 813, were shown to exhibit potent activity against a broad spectrum of aerobic and anaerobic bacteria in vitro. The activity of these agents in vitro translated well to chemo therapeutic activity in experimental bacteremias in mice. Substitution of the thiadiazine moiety of L-642, 946 with a triazine moiety effected a marked change in the pharmacokinetics of the new derivative, L-652, 813. In mice given a 20mg/kg subcutaneous dose, the peak serum concentration and the half-life of L-652, 813 were about three times greater than those of L-642, 946 and the area under the serum concentration/time curve was increased by about 5-fold. The pharmacokinetics of L-652, 813 in mice and in rhesus monkeys more closely resembled those of ceftriaxone which carries the same triazine moiety on the C-3 side chain." @default.
• W2003193691 created "2016-06-24" @default.
• W2003193691 creator A5000453596 @default.
• W2003193691 creator A5021036032 @default.
• W2003193691 creator A5028671740 @default.
• W2003193691 creator A5089658325 @default.
• W2003193691 date "1987-01-01" @default.
• W2003193691 modified "2023-09-26" @default.
• W2003193691 title "Quaternary heterocyclylamino .BETA.-lactams. VI In vitro and in vivo antibacterial properties of L-642,946 and L-652,813, a long acting cephem." @default.
• W2003193691 cites W1499482268 @default.
• W2003193691 cites W1532541041 @default.
• W2003193691 cites W1802399488 @default.
• W2003193691 cites W1932993007 @default.
• W2003193691 cites W1964871385 @default.
• W2003193691 cites W1970371699 @default.
• W2003193691 cites W1974728819 @default.
• W2003193691 cites W1979983125 @default.
• W2003193691 cites W1983014584 @default.
• W2003193691 cites W1983854333 @default.
• W2003193691 cites W1986790126 @default.
• W2003193691 cites W1991665650 @default.
• W2003193691 cites W1992006277 @default.
• W2003193691 cites W1998343963 @default.
• W2003193691 cites W1999513678 @default.
• W2003193691 cites W2002984572 @default.
• W2003193691 cites W2005609863 @default.
• W2003193691 cites W2008985393 @default.
• W2003193691 cites W2011665992 @default.
• W2003193691 cites W2025884734 @default.
• W2003193691 cites W2040778872 @default.
• W2003193691 cites W2054632049 @default.
• W2003193691 cites W2060561490 @default.
• W2003193691 cites W2065514514 @default.
• W2003193691 cites W2066420247 @default.
• W2003193691 cites W2067358735 @default.
• W2003193691 cites W2071845157 @default.
• W2003193691 cites W2082781882 @default.
• W2003193691 cites W2086950958 @default.
• W2003193691 cites W2088398586 @default.
• W2003193691 cites W2088928799 @default.
• W2003193691 cites W2088966739 @default.
• W2003193691 cites W2094117999 @default.
• W2003193691 cites W2105608467 @default.
• W2003193691 cites W2107241243 @default.
• W2003193691 cites W2123284927 @default.
• W2003193691 cites W2132129865 @default.
• W2003193691 cites W2135221146 @default.
• W2003193691 cites W2143487801 @default.
• W2003193691 cites W2145869667 @default.
• W2003193691 cites W2161869258 @default.
• W2003193691 cites W2165083290 @default.
• W2003193691 cites W2170217180 @default.
• W2003193691 cites W2281198901 @default.
• W2003193691 cites W2415527949 @default.
• W2003193691 cites W2463868232 @default.
• W2003193691 cites W2420619560 @default.
• W2003193691 doi "https://doi.org/10.7164/antibiotics.40.354" @default.
• W2003193691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3570988" @default.
• W2003193691 hasPublicationYear "1987" @default.
• W2003193691 type Work @default.
• W2003193691 sameAs 2003193691 @default.
• W2003193691 citedByCount "4" @default.
• W2003193691 countsByYear W20031936912012 @default.
• W2003193691 crossrefType "journal-article" @default.
• W2003193691 hasAuthorship W2003193691A5000453596 @default.
• W2003193691 hasAuthorship W2003193691A5021036032 @default.
• W2003193691 hasAuthorship W2003193691A5028671740 @default.
• W2003193691 hasAuthorship W2003193691A5089658325 @default.
• W2003193691 hasBestOaLocation W20031936911 @default.
• W2003193691 hasConcept C112705442 @default.
• W2003193691 hasConcept C150903083 @default.
• W2003193691 hasConcept C178790620 @default.
• W2003193691 hasConcept C185592680 @default.
• W2003193691 hasConcept C202751555 @default.
• W2003193691 hasConcept C207001950 @default.
• W2003193691 hasConcept C2776303721 @default.
• W2003193691 hasConcept C2776368647 @default.
• W2003193691 hasConcept C2776520383 @default.
• W2003193691 hasConcept C2776568683 @default.
• W2003193691 hasConcept C2779074116 @default.
• W2003193691 hasConcept C2780104969 @default.
• W2003193691 hasConcept C501593827 @default.
• W2003193691 hasConcept C523546767 @default.
• W2003193691 hasConcept C54355233 @default.
• W2003193691 hasConcept C55493867 @default.
• W2003193691 hasConcept C64778159 @default.
• W2003193691 hasConcept C71240020 @default.
• W2003193691 hasConcept C71924100 @default.
• W2003193691 hasConcept C86803240 @default.
• W2003193691 hasConcept C98274493 @default.
• W2003193691 hasConceptScore W2003193691C112705442 @default.
• W2003193691 hasConceptScore W2003193691C150903083 @default.
• W2003193691 hasConceptScore W2003193691C178790620 @default.
• W2003193691 hasConceptScore W2003193691C185592680 @default.
• W2003193691 hasConceptScore W2003193691C202751555 @default.
• W2003193691 hasConceptScore W2003193691C207001950 @default.
• W2003193691 hasConceptScore W2003193691C2776303721 @default.
• W2003193691 hasConceptScore W2003193691C2776368647 @default.

• next