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• W2003193904 abstract "Treatment of patients with paracoccidioidomycosis is still a challenge. Patients present defective lymphoproliferation and IFN-gamma responses to the main Paracoccidioides brasiliensis antigen (gp43), which correlates with disease severity. Here, we demonstrated that the patients show also a defective synthesis of interleukin (IL)-12. Therefore, we attempted to revert this immune disfunction by adding IL-12 and neutralizing anti-IL-10 antibody to gp-43-stimulated peripheral blood mononuclear cell cultures. Both treatments increased IFN-gamma secretion to levels observed with healthy sensitized individuals, but affected proliferation only modestly. When combined, the treatments further increased IFN-gamma synthesis and cell proliferation. The addition of suboptimal concentrations of IL-2 also further increased the IL-12-mediated secretion of IFN-gamma. Interestingly, the immune modulation was mostly antigen-specific, since the responses to Candida albicans' antigen were not affected. These results suggest that appropriate immune intervention with cytokines and/or anti-cytokines may help in the treatment of PCM." @default.
• W2003193904 created "2016-06-24" @default.
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• W2003193904 date "2002-05-01" @default.
• W2003193904 modified "2023-10-16" @default.
• W2003193904 title "IL-12 AND NEUTRALIZATION OF ENDOGENOUS IL-10 REVERT THE IN VITRO ANTIGEN-SPECIFIC CELLULAR IMMUNOSUPPRESSION OF PARACOCCIDIOIDOMYCOSIS PATIENTS" @default.
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• W2003193904 doi "https://doi.org/10.1006/cyto.2002.0884" @default.
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