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• W2003194076 abstract "Objectifs. Étudier de façon prospective les lymphomes osseux primitifs (LOP) et les comparer aux lymphomes d’autres localisations (LNH) et aux lymphomes osseux secondaires (LOS). Méthodes. Vingt-huit LOP ont été inclus dans le protocole thérapeutique multicentrique LNH 87 du Groupe d’étude des lymphomes de l’adulte (GELA). Ils ont été comparés aux 2 932 LNH d’autres localisation et 219 LOS. Résultats. Les LOP : 17 hommes et 11 femmes, d’âge médian 48 ans (extrêmes : 18–69). L’atteinte était monostotique 17 fois (14 fois le squelette périphérique), polyostotique 9 fois. Âge < 60 ans : 86 % des LOP ; 59 % des LNH ; 55 % des LOS. Stade Ann-Arbor I-II/III-IV : 54/46 % des LOP ; 50/50 % des LNH, 20/80 % des LOS. Performance status à 0 ou 1 : 100 % des LOP ; 50 % des LNH, 20 % des LOS. Phénotype B : 89 % des LOP ; 85 % des LNH et des LOS. Histologie : LOP = 54 % de diffus grandes cellules, 11 % de diffus mixte ; LNH = 39 % de diffus grandes cellules, 13 % de diffus mixte, 8 % de diffus immunoblastiques ; LOS = 45 % de diffus grandes cellules, 10 % de diffus mixtes, 12 % de diffus immunoblastiques. Réponse complète ou partielle après traitement d’induction : 86 % des LOP ; 84 % des LNH ; 78 % des LOS. Survie globale à cinq ans : 65 % des LOP ; 50 % des LNH ; 40 % des LOS. Discussion . Les LOP s’individualisent par une meilleure survie. Cependant, l’impact de la radiothérapie en fin de traitement mériterait d’être mieux précisé et des facteurs pronostiques plus spécifiquement osseux dégagés. Objective . To conduct a prospective study of primary lymphoma of bone (PLB) including comparisons to primary non-Hodgkin’s lymphoma (NHL) at other sites and to secondary lymphoma of bone (SLB). Methods . The 28 patients with PLB included in the 1987 NHL protocol developed by the GELA were studied and compared to 2932 patients with NHL at other sites and 219 patients with SLB. Results . Median age in the 28 PLB patients was 48 years (range, 18-69) ; there were 17 men and 11 women. The proportion of patients younger than 60 years was 86% in the PLB group, 59% in the other NHL group, and 55% in the SLB group. Proportions of Ann-Arbor stage patients (I-II/III-IV) were: 54%/46% in the PLB group, 50%/50% in the other NHLs group, and 20%/80% in the SLB group. Performance status was 0 or 1 in 100% of the PLB patients, 50% of the other NHLs patients, and 20% of the SLB patients. The tumor exhibited a B-cell phenotype in 89% of PLB patients and in 85% of other NHLs and SLB patients. Histological patterns were distributed as follows : PLB, 54% of diffuse large cell tumors and 11% of diffuse mixed cell tumors ; other NHLs, 39% of diffuse large cell tumors, 13% of diffuse mixed cell tumors, and 8% of diffuse immunoblastic tumors; SLB, 45% of diffuse large cell tumors, 10% of diffuse mixed cell tumors, and 12% of diffuse immunoblastic tumors. Induction therapy was followed by a complete or partial response in 86% of the PLB patients, 84% of the other NHL patients, and 78% of the SLB patients. Overall five-year survival was 65%, 50%, and 40% in these three groups, respectively. Discussion . Survival was better in the PLB group. Further work is needed to determine the impact of radiation therapy at the end of treatment and to identify prognostic factors specific to PLB." @default.
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• W2003194076 title "Lymphomes osseux primitifs : étude prospective de 28 cas" @default.
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• W2003194076 doi "https://doi.org/10.1016/s1169-8330(00)00018-1" @default.
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