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- W2003194611 abstract "The ultrastructural features of lymphocytes stimulated in vitro with phytohemagglutinin (PHA), pokeweed mitogen (PWM), and concanavalin A (Con A) from normal individuals and patients with chronic lymphocytic leukemia (CLL) were studied. With PHA and Con A the transformed cells had characteristics of blasts, and with PWM both blast cells and plasmacytoid cells occurred. The mean total cell area, the nuclear and cytoplasmic size, and the number of lysosomes were diminished in mitogen- transformed CLL cells as compared to transformed normal lymphocytes. Some stimulated CLL lymphocytes were indistinguishable from normal cells. The results suggest that the CLL lymphocytes which are transformed by phytomitogens could be derived from defective leukemic cells and/or a residual population of normal T and B cells." @default.
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- W2003194611 date "1973-07-01" @default.
- W2003194611 modified "2023-09-23" @default.
- W2003194611 title "Ultrastructural comparison between phytomitogen transformed normal and chronic lymphocytic leukemia lymphocytes" @default.
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- W2003194611 doi "https://doi.org/10.1016/s0022-5320(73)90013-0" @default.
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