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- W2003195498 abstract "1-Amino-N-propargylaminoindan (rasagiline) is now under phase 3 clinical trials for the treatment of Parkinson's disease (PD). In vivo and in vitro experiments using animal and cellular PD models proved that rasagiline protects neurons from cytotoxicity of various insults. Rasagiline prevents apoptosis induced by a dopaminergic neurotoxin, N-methyl(R)salsolinol in dopaminergic SH-SY5Y cells. It suppressed the decline in mitochondrial membrane potential, and following activation of apoptotic cascade. The stabilization of mitochondria membrane potential was confirmed also in isolated mitochondria. To examine the effect of rasagiline on antiapoptotic bcl-2 gene expression, the levels of mRNA and protein of Bcl-2 protein family were examined in SH-SY5Y cells treated with rasagiline. The levels of antiapoptotic bcl-2 and bcl-xL increased significantly, but those of pro-apoptotic bax and bad were not. The study on the structure-activity relationship among propargylamines revealed the chemical structure required for the stabilization of PT and the induction of bcl-2 genes, respectively. In addition, rasagiline increased the level of glial cell line-derived nutrition factor (GDNF). The results suggest that rasagiline protects neurons by increased expression of cyto-protective genes, and may rescue declining neurons in PD and other neurodegenerative disorders." @default.
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- W2003195498 date "2008-06-28" @default.
- W2003195498 modified "2023-09-27" @default.
- W2003195498 title "Molecular mechanism underlying neuroprotection by rasagiline" @default.
- W2003195498 doi "https://doi.org/10.1046/j.1471-4159.2002.00012.x" @default.
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