FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003195641> ?p ?o ?g. }

• W2003195641 endingPage "23851" @default.
• W2003195641 startingPage "23846" @default.
• W2003195641 abstract "Sulfiredoxin (Srx) catalyzes a novel enzymatic reaction, the reduction of protein cysteine sulfinic acid, Cys-SO(2)(-). This reaction is unique to the typical 2-Cys peroxiredoxins (Prx) and plays a role in peroxide-mediated signaling by regulating the activity of Prxs. Two mechanistic schemes have been proposed that differ regarding the first step of the reaction. This step involves either the direct transfer of the gamma-phosphate of ATP to the Prx molecule or through Srx acting as a phosphorylated intermediary. In an effort to clarify this step of the Srx reaction, we have determined the 1.8A resolution crystal structure of Srx in complex with ATP and Mg(2+). This structure reveals the role of the Mg(2+) ion to position the gamma-phosphate toward solvent, thus preventing an in-line attack by the catalytic residue Cys-99 of Srx. A model of the quaternary complex is consistent with this proposal. Furthermore, phosphorylation studies on several site-directed mutants of Srx and Prx, including the Prx-Asp mimic of the Prx-SO(2)(-) species, support a mechanism where phosphorylation of Prx-SO(2)(-) is the first chemical step." @default.
• W2003195641 created "2016-06-24" @default.
• W2003195641 creator A5016623498 @default.
• W2003195641 creator A5026931975 @default.
• W2003195641 creator A5050688711 @default.
• W2003195641 creator A5090966947 @default.
• W2003195641 date "2008-08-01" @default.
• W2003195641 modified "2023-09-26" @default.
• W2003195641 title "Reduction of Cysteine Sulfinic Acid in Peroxiredoxin by Sulfiredoxin Proceeds Directly through a Sulfinic Phosphoryl Ester Intermediate" @default.
• W2003195641 cites W1485027271 @default.
• W2003195641 cites W1586029261 @default.
• W2003195641 cites W1921965616 @default.
• W2003195641 cites W1974966731 @default.
• W2003195641 cites W1985776151 @default.
• W2003195641 cites W1987350479 @default.
• W2003195641 cites W1993058298 @default.
• W2003195641 cites W1995017064 @default.
• W2003195641 cites W2001991555 @default.
• W2003195641 cites W2002850755 @default.
• W2003195641 cites W2006569015 @default.
• W2003195641 cites W2008203769 @default.
• W2003195641 cites W2017642315 @default.
• W2003195641 cites W2022786966 @default.
• W2003195641 cites W2029418709 @default.
• W2003195641 cites W2038840577 @default.
• W2003195641 cites W2043929237 @default.
• W2003195641 cites W2049713754 @default.
• W2003195641 cites W2051687003 @default.
• W2003195641 cites W2062901635 @default.
• W2003195641 cites W2067073417 @default.
• W2003195641 cites W2088411222 @default.
• W2003195641 cites W2098039543 @default.
• W2003195641 cites W2101032933 @default.
• W2003195641 cites W2110096570 @default.
• W2003195641 cites W2123722691 @default.
• W2003195641 cites W2134216529 @default.
• W2003195641 cites W2144081223 @default.
• W2003195641 cites W2147228426 @default.
• W2003195641 cites W2158496331 @default.
• W2003195641 doi "https://doi.org/10.1074/jbc.m803244200" @default.
• W2003195641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2527103" @default.
• W2003195641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18579529" @default.
• W2003195641 hasPublicationYear "2008" @default.
• W2003195641 type Work @default.
• W2003195641 sameAs 2003195641 @default.
• W2003195641 citedByCount "74" @default.
• W2003195641 countsByYear W20031956412012 @default.
• W2003195641 countsByYear W20031956412013 @default.
• W2003195641 countsByYear W20031956412014 @default.
• W2003195641 countsByYear W20031956412015 @default.
• W2003195641 countsByYear W20031956412016 @default.
• W2003195641 countsByYear W20031956412017 @default.
• W2003195641 countsByYear W20031956412018 @default.
• W2003195641 countsByYear W20031956412019 @default.
• W2003195641 countsByYear W20031956412020 @default.
• W2003195641 countsByYear W20031956412022 @default.
• W2003195641 countsByYear W20031956412023 @default.
• W2003195641 crossrefType "journal-article" @default.
• W2003195641 hasAuthorship W2003195641A5016623498 @default.
• W2003195641 hasAuthorship W2003195641A5026931975 @default.
• W2003195641 hasAuthorship W2003195641A5050688711 @default.
• W2003195641 hasAuthorship W2003195641A5090966947 @default.
• W2003195641 hasBestOaLocation W20031956411 @default.
• W2003195641 hasConcept C11960822 @default.
• W2003195641 hasConcept C162008176 @default.
• W2003195641 hasConcept C178790620 @default.
• W2003195641 hasConcept C181199279 @default.
• W2003195641 hasConcept C185592680 @default.
• W2003195641 hasConcept C2779201268 @default.
• W2003195641 hasConcept C2780158455 @default.
• W2003195641 hasConcept C2780416994 @default.
• W2003195641 hasConcept C2780731314 @default.
• W2003195641 hasConcept C55493867 @default.
• W2003195641 hasConceptScore W2003195641C11960822 @default.
• W2003195641 hasConceptScore W2003195641C162008176 @default.
• W2003195641 hasConceptScore W2003195641C178790620 @default.
• W2003195641 hasConceptScore W2003195641C181199279 @default.
• W2003195641 hasConceptScore W2003195641C185592680 @default.
• W2003195641 hasConceptScore W2003195641C2779201268 @default.
• W2003195641 hasConceptScore W2003195641C2780158455 @default.
• W2003195641 hasConceptScore W2003195641C2780416994 @default.
• W2003195641 hasConceptScore W2003195641C2780731314 @default.
• W2003195641 hasConceptScore W2003195641C55493867 @default.
• W2003195641 hasIssue "35" @default.
• W2003195641 hasLocation W20031956411 @default.
• W2003195641 hasLocation W20031956412 @default.
• W2003195641 hasLocation W20031956413 @default.
• W2003195641 hasLocation W20031956414 @default.
• W2003195641 hasOpenAccess W2003195641 @default.
• W2003195641 hasPrimaryLocation W20031956411 @default.
• W2003195641 hasRelatedWork W2041115865 @default.
• W2003195641 hasRelatedWork W2044075759 @default.
• W2003195641 hasRelatedWork W2049713754 @default.
• W2003195641 hasRelatedWork W205714514 @default.
• W2003195641 hasRelatedWork W2057492923 @default.
• W2003195641 hasRelatedWork W2058726923 @default.
• W2003195641 hasRelatedWork W2075584603 @default.
• W2003195641 hasRelatedWork W2169482201 @default.

• next