Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003197654> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2003197654 endingPage "83" @default.
- W2003197654 startingPage "80" @default.
- W2003197654 abstract "The human colonic cell line Caco-2 responds to a reduction of ambient [Ca++]oto levels at and below 0.25 mM by a twofold increase in [3H]thymidine labelling of their DNA. [Ca++]osignals sensed preferentially across the luminal aspect of Caco-2 cells, are rapidly (4 h) transduced via PKC activation into up to sixfold increases in c-mycexpression. This suggests the presence of a [Ca++]o-sensing membrane receptor (CaR) similar to that described by Brown et al. (1) in parathyroid and kidney cells. By RT-PCR we were able to amplify a 426 bp fragment from Caco-2 mRNA with 98% nucleotide identity to a part of the coding region for the extracellular domain of the parathyroid CaR. Immunohistochemical staining with a monoclonal anti-parathyroid CaR antibody demonstrates CaR protein at the plasma membrane of confluent Caco-2 cells. Our results imply that the intestinal CaR is a potential mediator for the transduction of low luminal [Ca++]ointo tumor promoting signals in human colonocytes" @default.
- W2003197654 created "2016-06-24" @default.
- W2003197654 creator A5000367642 @default.
- W2003197654 creator A5011522097 @default.
- W2003197654 creator A5036594335 @default.
- W2003197654 creator A5038281830 @default.
- W2003197654 creator A5077481159 @default.
- W2003197654 creator A5082754392 @default.
- W2003197654 creator A5087663508 @default.
- W2003197654 date "1997-03-01" @default.
- W2003197654 modified "2023-10-17" @default.
- W2003197654 title "Calcium-Dependent c-mycProto-Oncogene Expression and Proliferation of CACO-2 Cells: A Role for a Luminal Extracellular Calcium-Sensing Receptor" @default.
- W2003197654 cites W1569207530 @default.
- W2003197654 cites W1577088219 @default.
- W2003197654 cites W1971159467 @default.
- W2003197654 cites W2009441758 @default.
- W2003197654 cites W2045978276 @default.
- W2003197654 cites W2090227738 @default.
- W2003197654 cites W2116594884 @default.
- W2003197654 cites W2170949021 @default.
- W2003197654 cites W2403795152 @default.
- W2003197654 doi "https://doi.org/10.1006/bbrc.1997.6225" @default.
- W2003197654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9125156" @default.
- W2003197654 hasPublicationYear "1997" @default.
- W2003197654 type Work @default.
- W2003197654 sameAs 2003197654 @default.
- W2003197654 citedByCount "119" @default.
- W2003197654 countsByYear W20031976542012 @default.
- W2003197654 countsByYear W20031976542013 @default.
- W2003197654 countsByYear W20031976542014 @default.
- W2003197654 countsByYear W20031976542015 @default.
- W2003197654 countsByYear W20031976542016 @default.
- W2003197654 countsByYear W20031976542017 @default.
- W2003197654 countsByYear W20031976542018 @default.
- W2003197654 countsByYear W20031976542019 @default.
- W2003197654 countsByYear W20031976542020 @default.
- W2003197654 countsByYear W20031976542022 @default.
- W2003197654 countsByYear W20031976542023 @default.
- W2003197654 crossrefType "journal-article" @default.
- W2003197654 hasAuthorship W2003197654A5000367642 @default.
- W2003197654 hasAuthorship W2003197654A5011522097 @default.
- W2003197654 hasAuthorship W2003197654A5036594335 @default.
- W2003197654 hasAuthorship W2003197654A5038281830 @default.
- W2003197654 hasAuthorship W2003197654A5077481159 @default.
- W2003197654 hasAuthorship W2003197654A5082754392 @default.
- W2003197654 hasAuthorship W2003197654A5087663508 @default.
- W2003197654 hasConcept C142590548 @default.
- W2003197654 hasConcept C1491633281 @default.
- W2003197654 hasConcept C153911025 @default.
- W2003197654 hasConcept C170493617 @default.
- W2003197654 hasConcept C178790620 @default.
- W2003197654 hasConcept C185592680 @default.
- W2003197654 hasConcept C193176779 @default.
- W2003197654 hasConcept C2781208988 @default.
- W2003197654 hasConcept C28406088 @default.
- W2003197654 hasConcept C519063684 @default.
- W2003197654 hasConcept C54355233 @default.
- W2003197654 hasConcept C55493867 @default.
- W2003197654 hasConcept C62478195 @default.
- W2003197654 hasConcept C81885089 @default.
- W2003197654 hasConcept C86803240 @default.
- W2003197654 hasConcept C95444343 @default.
- W2003197654 hasConceptScore W2003197654C142590548 @default.
- W2003197654 hasConceptScore W2003197654C1491633281 @default.
- W2003197654 hasConceptScore W2003197654C153911025 @default.
- W2003197654 hasConceptScore W2003197654C170493617 @default.
- W2003197654 hasConceptScore W2003197654C178790620 @default.
- W2003197654 hasConceptScore W2003197654C185592680 @default.
- W2003197654 hasConceptScore W2003197654C193176779 @default.
- W2003197654 hasConceptScore W2003197654C2781208988 @default.
- W2003197654 hasConceptScore W2003197654C28406088 @default.
- W2003197654 hasConceptScore W2003197654C519063684 @default.
- W2003197654 hasConceptScore W2003197654C54355233 @default.
- W2003197654 hasConceptScore W2003197654C55493867 @default.
- W2003197654 hasConceptScore W2003197654C62478195 @default.
- W2003197654 hasConceptScore W2003197654C81885089 @default.
- W2003197654 hasConceptScore W2003197654C86803240 @default.
- W2003197654 hasConceptScore W2003197654C95444343 @default.
- W2003197654 hasIssue "1" @default.
- W2003197654 hasLocation W20031976541 @default.
- W2003197654 hasLocation W20031976542 @default.
- W2003197654 hasOpenAccess W2003197654 @default.
- W2003197654 hasPrimaryLocation W20031976541 @default.
- W2003197654 hasRelatedWork W1963863557 @default.
- W2003197654 hasRelatedWork W1971517874 @default.
- W2003197654 hasRelatedWork W1975286132 @default.
- W2003197654 hasRelatedWork W2024105354 @default.
- W2003197654 hasRelatedWork W2034026153 @default.
- W2003197654 hasRelatedWork W2037989165 @default.
- W2003197654 hasRelatedWork W2070112429 @default.
- W2003197654 hasRelatedWork W2084474801 @default.
- W2003197654 hasRelatedWork W2084593131 @default.
- W2003197654 hasRelatedWork W2140800174 @default.
- W2003197654 hasVolume "232" @default.
- W2003197654 isParatext "false" @default.
- W2003197654 isRetracted "false" @default.
- W2003197654 magId "2003197654" @default.
- W2003197654 workType "article" @default.