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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003197964> ?p ?o ?g. }

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• W2003197964 abstract "Recent studies have suggested that global intracellular Ca2+ signals arise from the summation and coordination of subcellular elementary release events (e.g., “Ca2+ puffs”), although the modes of recruitment of such signals are unknown. In order to understand how cells utilize elementary Ca2+ release events, we imaged Ca2+ transients evoked through the phosphoinositide pathway in HeLa cells using confocal microscopy. During the pacemaker phase leading to the global Ca2+ signal, elementary Ca2+ release events were recruited in (1) frequency, (2) amplitude, and (3) spatial domains. Since each digital elementary event contributes to a small change of the analog cytosolic Ca2+ concentration, the net effect of the advancement in the three domains is to drive the ambient Ca2+ concentration toward a threshold where the signal becomes regenerative, resulting in a global Ca2+ wave." @default.
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• W2003197964 date "1997-10-01" @default.
• W2003197964 modified "2023-10-17" @default.
• W2003197964 title "Cooking with Calcium: The Recipes for Composing Global Signals from Elementary Events" @default.
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• W2003197964 doi "https://doi.org/10.1016/s0092-8674(00)80420-1" @default.
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