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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003199002> ?p ?o ?g. }

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• W2003199002 abstract "GPR48 can mediate keratinocyte proliferation and migration. Our investigations showed that AG1478, an inhibitor of EGFR tyrosine kinase, could block GPR48-mediated cellular processes. AG1478 treatment of Gpr48 +/+ cells also decreased phosphorylation of EGFR, ERK and STAT3. Subsequent screening using conditioned media immunodepleted of EGFR ligands identified HB-EGF as the ligand responsible for phosphorylation of EGFR, ERK and STAT3. HB-EGF was reduced in Gpr48 −/− cell culture medium, but its addition restored the phosphorylation of EGFR, ERK, STAT3, as well as cell proliferation. Confirmation that GPR48 mediates EGFR signaling pathway through HB-EGF was subsequently performed using an inhibitor of HB-EGF." @default.
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• W2003199002 date "2010-08-21" @default.
• W2003199002 modified "2023-09-26" @default.
• W2003199002 title "GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation" @default.
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• W2003199002 doi "https://doi.org/10.1016/j.febslet.2010.08.028" @default.
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