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• W2003199248 abstract "Background and Purpose— The concept of neuroprotection is based on sound scientific data derived in preclinical studies. However, candidate neuroprotectants have never been successfully translated to patients. Methods— A review of past approaches to cellular and molecular neuroprotection, preclinical neuroprotection studies, and clinical approaches was undertaken. Results— Although there is no evidence for fundamental barriers in biological principles that limit the translation of promising therapies to humans, ample evidence exists as to a lack of rigor in preclinical studies, obstacles posed by the complexities of acute ischemic stroke syndromes, and regulatory barriers. Alternative methods to translating stroke drugs may require trials in restricted stroke indications in well-defined patient populations. Conclusions— The translational gap between cellular and molecular neuroscience and patient therapy may be bridged by first developing therapies for narrow stroke indications. A single success may stimulate further research, funding, and a capacity to generalize initial results to broader stroke populations." @default.
• W2003199248 created "2016-06-24" @default.
• W2003199248 creator A5018456621 @default.
• W2003199248 date "2010-10-01" @default.
• W2003199248 modified "2023-09-27" @default.
• W2003199248 title "Can Molecular and Cellular Neuroprotection Be Translated Into Therapies for Patients?" @default.
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• W2003199248 doi "https://doi.org/10.1161/strokeaha.110.595496" @default.
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