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- W2003200870 abstract "Stress-induced increase in intracellular calcium (Ca2+) has been demonstrated to produce various deleterious effects in the body. The rise in intracellular Ca2+ (particularly neuronal) in response to stress has been mainly attributed to opening of voltage gated L-type Ca2+ channels. The role of P/Q-, N-, R- and T-type Ca2+channels, and plasma membrane localized exchangers such as Na+/Ca2+ exchanger and Ca2+ ATPase has also been implicated in increasing intracellular Ca2+ in response to stress. Stress-induced changes in Ca2+ currents has been mainly attributed to increased release of corticosterone (activation of glucocorticoid receptors in the hippocampus) and catecholamine release as a consequence of activation of Hypothalamic–Pituitary–Adrenal (HPA) axis and sympathetic neural system, respectively. Stress-induced increase intracellular Ca2+ may trigger various deleterious signaling pathway including free radical generation, apoptosis, increased synaptic release of glutamate and synthesis/release of cytotoxic cytokines that may be responsible for damaging effects associated with stress. The present review discusses the mechanisms involved in stress-induced rise in intracellular Ca2+ levels and subsequent implications of increased Ca2+ levels in stress." @default.
- W2003200870 created "2016-06-24" @default.
- W2003200870 creator A5011711095 @default.
- W2003200870 creator A5026552502 @default.
- W2003200870 creator A5064947153 @default.
- W2003200870 creator A5078623083 @default.
- W2003200870 date "2013-08-01" @default.
- W2003200870 modified "2023-09-23" @default.
- W2003200870 title "Implicating the role of plasma membrane localized calcium channels and exchangers in stress-induced deleterious effects" @default.
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