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- W2003201206 endingPage "244" @default.
- W2003201206 startingPage "233" @default.
- W2003201206 abstract "The aged heart has a diminished functional and adaptive reserve capacity, an increased susceptibility to incur damage (e.g., as a result of ischemia), and a limited practical ability for repair/regeneration. Thus, there has been considerable interest to harness the heart's endogenous capacity to resist such damage, known as ischemic preconditioning (IPC), as well as other cardioprotective mechanisms. However, the translation of basic research findings into clinical practice has largely been inadequate because there have been few if any successful implementations in terms of viable therapies activating cardioprotection mechanisms to limit infarct size. Here, we provide an overview of the general mechanisms of cardioprotection, changes in the structure and function of the aged heart, and the current knowledge regarding cardioprotection in aged heart. The problems and opportunities for successful bench-to-bedside translation of cardioprotection in the elderly are discussed." @default.
- W2003201206 created "2016-06-24" @default.
- W2003201206 creator A5047166519 @default.
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- W2003201206 creator A5060742163 @default.
- W2003201206 creator A5064857408 @default.
- W2003201206 creator A5081151780 @default.
- W2003201206 date "2005-05-01" @default.
- W2003201206 modified "2023-10-02" @default.
- W2003201206 title "Protection in the aged heart: preventing the heart-break of old age?" @default.
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