Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003202154> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2003202154 endingPage "995" @default.
- W2003202154 startingPage "983" @default.
- W2003202154 abstract "1. The synthesis of the pineal hormone, melatonin, is under adrenergic control. The brain's rhythm generating system (suprachiasmatic nucleus and associated systems) which is synchronised by the light-dark cycle controls norepinephrine release from the sympathetic nerve terminal resulting in cAMP accumulation. Increased cAMP leads to induction of the rate-limiting enzyme, N-acetyltransferase and synthesis of melatonin. The pineal exhibits a circadian rhythm with highest blood levels of the hormone being present during the night. The circadian rhythm of melatonin production provides important time-of-day and time-of-year information and, as a result, this hormonal cycle drives other 24-hour rhythms as well as seasonal cycles of reproduction, at least in photoperiodic mammals. 2. Chronic alcoholics were withdrawn from alcohol during a continued period of 4 days and nights. Blood samples were drawn from an indwelling venous catheter and sleep was monitored with polysomnography. No medication was used. No alcohol intake was allowed after admission. Bright light treatment was applied during day 3 of the study. 3. During the 4 days of alcohol-withdrawal the night time melatonin-secretion was disrupted. More than 50% of the patients had a very low secretion (< 30 pg/ml) which did not normalize during the study period. Psychopathology, sleep quality and sleep architecture improved significantly. The melatonin secretion pattern showed low values throughout the study. This low melatonin secretion might reflect the long lasting toxic influence of alcohol on the biological clock and/or a direct inhibitory effect on pineal function. These are different effects, although interrelated. 4. Ethanol has a direct inhibitory effect on pineal melatonin synthesis. A well-recognized action of ethanol is its ability to permeate and perturb the structure of cell membranes and may be related to its lipophilic properties. The changes in membrane fluidity seem to last longer than the study period of 4 days." @default.
- W2003202154 created "2016-06-24" @default.
- W2003202154 creator A5002702735 @default.
- W2003202154 creator A5022238857 @default.
- W2003202154 creator A5042261753 @default.
- W2003202154 creator A5052406543 @default.
- W2003202154 date "1996-08-01" @default.
- W2003202154 modified "2023-09-28" @default.
- W2003202154 title "Disrupted melatonin-secretion during alcohol withdrawal" @default.
- W2003202154 cites W1967270485 @default.
- W2003202154 cites W1972198114 @default.
- W2003202154 cites W2008125730 @default.
- W2003202154 cites W2008562243 @default.
- W2003202154 cites W2010941012 @default.
- W2003202154 cites W2011836508 @default.
- W2003202154 cites W2066573662 @default.
- W2003202154 cites W2087963100 @default.
- W2003202154 cites W2115155158 @default.
- W2003202154 cites W2121676473 @default.
- W2003202154 cites W2141516733 @default.
- W2003202154 cites W2156748734 @default.
- W2003202154 cites W2238707145 @default.
- W2003202154 cites W2494399378 @default.
- W2003202154 cites W353969420 @default.
- W2003202154 doi "https://doi.org/10.1016/0278-5846(96)00078-4" @default.
- W2003202154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8888105" @default.
- W2003202154 hasPublicationYear "1996" @default.
- W2003202154 type Work @default.
- W2003202154 sameAs 2003202154 @default.
- W2003202154 citedByCount "40" @default.
- W2003202154 countsByYear W20032021542012 @default.
- W2003202154 countsByYear W20032021542013 @default.
- W2003202154 countsByYear W20032021542014 @default.
- W2003202154 countsByYear W20032021542015 @default.
- W2003202154 countsByYear W20032021542016 @default.
- W2003202154 countsByYear W20032021542017 @default.
- W2003202154 countsByYear W20032021542018 @default.
- W2003202154 countsByYear W20032021542020 @default.
- W2003202154 countsByYear W20032021542022 @default.
- W2003202154 countsByYear W20032021542023 @default.
- W2003202154 crossrefType "journal-article" @default.
- W2003202154 hasAuthorship W2003202154A5002702735 @default.
- W2003202154 hasAuthorship W2003202154A5022238857 @default.
- W2003202154 hasAuthorship W2003202154A5042261753 @default.
- W2003202154 hasAuthorship W2003202154A5052406543 @default.
- W2003202154 hasConcept C121446783 @default.
- W2003202154 hasConcept C126322002 @default.
- W2003202154 hasConcept C134018914 @default.
- W2003202154 hasConcept C201176492 @default.
- W2003202154 hasConcept C2778182776 @default.
- W2003202154 hasConcept C2779317972 @default.
- W2003202154 hasConcept C2780059843 @default.
- W2003202154 hasConcept C38606739 @default.
- W2003202154 hasConcept C71315377 @default.
- W2003202154 hasConcept C71924100 @default.
- W2003202154 hasConcept C86803240 @default.
- W2003202154 hasConceptScore W2003202154C121446783 @default.
- W2003202154 hasConceptScore W2003202154C126322002 @default.
- W2003202154 hasConceptScore W2003202154C134018914 @default.
- W2003202154 hasConceptScore W2003202154C201176492 @default.
- W2003202154 hasConceptScore W2003202154C2778182776 @default.
- W2003202154 hasConceptScore W2003202154C2779317972 @default.
- W2003202154 hasConceptScore W2003202154C2780059843 @default.
- W2003202154 hasConceptScore W2003202154C38606739 @default.
- W2003202154 hasConceptScore W2003202154C71315377 @default.
- W2003202154 hasConceptScore W2003202154C71924100 @default.
- W2003202154 hasConceptScore W2003202154C86803240 @default.
- W2003202154 hasIssue "6" @default.
- W2003202154 hasLocation W20032021541 @default.
- W2003202154 hasLocation W20032021542 @default.
- W2003202154 hasOpenAccess W2003202154 @default.
- W2003202154 hasPrimaryLocation W20032021541 @default.
- W2003202154 hasRelatedWork W130316259 @default.
- W2003202154 hasRelatedWork W1974854913 @default.
- W2003202154 hasRelatedWork W1979779439 @default.
- W2003202154 hasRelatedWork W2045101379 @default.
- W2003202154 hasRelatedWork W2047507940 @default.
- W2003202154 hasRelatedWork W2102842013 @default.
- W2003202154 hasRelatedWork W2111882322 @default.
- W2003202154 hasRelatedWork W2127194509 @default.
- W2003202154 hasRelatedWork W2186391652 @default.
- W2003202154 hasRelatedWork W2364002261 @default.
- W2003202154 hasVolume "20" @default.
- W2003202154 isParatext "false" @default.
- W2003202154 isRetracted "false" @default.
- W2003202154 magId "2003202154" @default.
- W2003202154 workType "article" @default.