Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003202491> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2003202491 endingPage "333" @default.
- W2003202491 startingPage "322" @default.
- W2003202491 abstract "Purpose Heterochromatin protein 1γ (HP1γ) interacts with chromosomes by binding to lysine 9-methylated histone H3 or DNA/RNA. HP1γ is involved in various biological processes. The purpose of this study is to gain an understanding of how HP1γ functions in these processes by identifying HP1γ-binding proteins using mass spectrometry. Materials and Methods We performed affinity purification of HP1γ-binding proteins using G1/S phase or prometaphase HEK293T cell lysates that transiently express mock or FLAG-HP1γ. Coomassie staining was performed for HP1γ-binding complexes, using cell lysates prepared by affinity chromatography FLAG-agarose beads, and the bands were digested and then analyzed using a mass spectrometry. Results We identified 99 HP1γ-binding proteins with diverse cellular functions, including spliceosome, regulation of the actin cytoskeleton, tight junction, pathogenic Escherichia coli infection, mammalian target of rapamycin signaling pathway, nucleotide excision repair, DNA replication, homologous recombination, and mismatch repair. Conclusion Our results suggested that HP1γ is functionally active in DNA damage response via protein-protein interaction. Key words: HP1γ, Protein interaction, DNA damage response" @default.
- W2003202491 created "2016-06-24" @default.
- W2003202491 creator A5005259900 @default.
- W2003202491 creator A5007382558 @default.
- W2003202491 creator A5024610841 @default.
- W2003202491 creator A5033726593 @default.
- W2003202491 creator A5089428099 @default.
- W2003202491 date "2016-01-15" @default.
- W2003202491 modified "2023-10-18" @default.
- W2003202491 title "Interactome Analysis Reveals that Heterochromatin Protein 1γ (HP1γ) Is Associated with the DNA Damage Response Pathway" @default.
- W2003202491 cites W1990672687 @default.
- W2003202491 cites W1991125055 @default.
- W2003202491 cites W1997948377 @default.
- W2003202491 cites W2014895093 @default.
- W2003202491 cites W2026501344 @default.
- W2003202491 cites W2027088029 @default.
- W2003202491 cites W2032855356 @default.
- W2003202491 cites W2040285686 @default.
- W2003202491 cites W2045981425 @default.
- W2003202491 cites W2049874714 @default.
- W2003202491 cites W2086556990 @default.
- W2003202491 cites W2100479353 @default.
- W2003202491 cites W2110399580 @default.
- W2003202491 cites W2121437237 @default.
- W2003202491 cites W2139460080 @default.
- W2003202491 cites W2146021974 @default.
- W2003202491 cites W2153825225 @default.
- W2003202491 cites W2156814170 @default.
- W2003202491 doi "https://doi.org/10.4143/crt.2014.294" @default.
- W2003202491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4720079" @default.
- W2003202491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25761473" @default.
- W2003202491 hasPublicationYear "2016" @default.
- W2003202491 type Work @default.
- W2003202491 sameAs 2003202491 @default.
- W2003202491 citedByCount "6" @default.
- W2003202491 countsByYear W20032024912017 @default.
- W2003202491 countsByYear W20032024912019 @default.
- W2003202491 countsByYear W20032024912020 @default.
- W2003202491 countsByYear W20032024912022 @default.
- W2003202491 countsByYear W20032024912023 @default.
- W2003202491 crossrefType "journal-article" @default.
- W2003202491 hasAuthorship W2003202491A5005259900 @default.
- W2003202491 hasAuthorship W2003202491A5007382558 @default.
- W2003202491 hasAuthorship W2003202491A5024610841 @default.
- W2003202491 hasAuthorship W2003202491A5033726593 @default.
- W2003202491 hasAuthorship W2003202491A5089428099 @default.
- W2003202491 hasBestOaLocation W20032024911 @default.
- W2003202491 hasConcept C103435993 @default.
- W2003202491 hasConcept C104317684 @default.
- W2003202491 hasConcept C134935766 @default.
- W2003202491 hasConcept C153911025 @default.
- W2003202491 hasConcept C552990157 @default.
- W2003202491 hasConcept C55493867 @default.
- W2003202491 hasConcept C64927066 @default.
- W2003202491 hasConcept C83640560 @default.
- W2003202491 hasConcept C86803240 @default.
- W2003202491 hasConcept C92149661 @default.
- W2003202491 hasConcept C95444343 @default.
- W2003202491 hasConcept C9760119 @default.
- W2003202491 hasConceptScore W2003202491C103435993 @default.
- W2003202491 hasConceptScore W2003202491C104317684 @default.
- W2003202491 hasConceptScore W2003202491C134935766 @default.
- W2003202491 hasConceptScore W2003202491C153911025 @default.
- W2003202491 hasConceptScore W2003202491C552990157 @default.
- W2003202491 hasConceptScore W2003202491C55493867 @default.
- W2003202491 hasConceptScore W2003202491C64927066 @default.
- W2003202491 hasConceptScore W2003202491C83640560 @default.
- W2003202491 hasConceptScore W2003202491C86803240 @default.
- W2003202491 hasConceptScore W2003202491C92149661 @default.
- W2003202491 hasConceptScore W2003202491C95444343 @default.
- W2003202491 hasConceptScore W2003202491C9760119 @default.
- W2003202491 hasFunder F4320322120 @default.
- W2003202491 hasIssue "1" @default.
- W2003202491 hasLocation W20032024911 @default.
- W2003202491 hasLocation W20032024912 @default.
- W2003202491 hasLocation W20032024913 @default.
- W2003202491 hasLocation W20032024914 @default.
- W2003202491 hasOpenAccess W2003202491 @default.
- W2003202491 hasPrimaryLocation W20032024911 @default.
- W2003202491 hasRelatedWork W2043419092 @default.
- W2003202491 hasRelatedWork W2044551569 @default.
- W2003202491 hasRelatedWork W2051008134 @default.
- W2003202491 hasRelatedWork W2059118851 @default.
- W2003202491 hasRelatedWork W2133084756 @default.
- W2003202491 hasRelatedWork W2743033273 @default.
- W2003202491 hasRelatedWork W2755595744 @default.
- W2003202491 hasRelatedWork W3167804293 @default.
- W2003202491 hasRelatedWork W3195682473 @default.
- W2003202491 hasRelatedWork W4281926650 @default.
- W2003202491 hasVolume "48" @default.
- W2003202491 isParatext "false" @default.
- W2003202491 isRetracted "false" @default.
- W2003202491 magId "2003202491" @default.
- W2003202491 workType "article" @default.