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- W2003203588 abstract "A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed. Inotrope Aktivität von Imidazopyridinen Es wurde eine Reihe von 2-substituierten 1H-Imidazo[4,5-b]-pyridinen und der isomeren 1H-Imidazo[4,5-c]pyridin-Derivate hergestellt und als inotrope Agentien evaluiert. Die 1H-Imidazo-[4,5-b]-Derivate erweisen sich als deutlich wirksamer als ihre Isomere in der [4,5-c] Reihe am isolierten Papillarmuskel des Meerschweinchens. Es werden die Verhältnisse zwischen Struktur und Aktivität sowie die Artenabhängigkeit der inotropen Wirksamkeit diskutiert." @default.
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- W2003203588 date "1990-01-01" @default.
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- W2003203588 title "Inotropic Activities of Imidazopyridines" @default.
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- W2003203588 doi "https://doi.org/10.1002/ardp.19903230811" @default.
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