FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003205330> ?p ?o ?g. }

• W2003205330 endingPage "e65751" @default.
• W2003205330 startingPage "e65751" @default.
• W2003205330 abstract "Unaccustomed strenuous exercise that includes lengthening contraction (LC) often causes tenderness and movement related pain after some delay (delayed-onset muscle soreness, DOMS). We previously demonstrated that nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) are up-regulated in exercised muscle through up-regulation of cyclooxygenase (COX)-2, and they sensitized nociceptors resulting in mechanical hyperalgesia. There is also a study showing that transient receptor potential (TRP) ion channels are involved in DOMS. Here we examined whether and how TRPV1 and/or TRPV4 are involved in DOMS. We firstly evaluated a method to measure the mechanical withdrawal threshold of the deep tissues in wild-type (WT) mice with a modified Randall-Selitto apparatus. WT, TRPV1−/− and TRPV4−/− mice were then subjected to LC. Another group of mice received injection of murine NGF-2.5S or GDNF to the lateral gastrocnemius (LGC) muscle. Before and after these treatments the mechanical withdrawal threshold of LGC was evaluated. The change in expression of NGF, GDNF and COX-2 mRNA in the muscle was examined using real-time RT-PCR. In WT mice, mechanical hyperalgesia was observed 6–24 h after LC and 1–24 h after NGF and GDNF injection. LC induced mechanical hyperalgesia neither in TRPV1−/− nor in TRPV4−/− mice. NGF injection induced mechanical hyperalgesia in WT and TRPV4−/− mice but not in TRPV1−/− mice. GDNF injection induced mechanical hyperalgesia in WT but neither in TRPV1−/− nor in TRPV4−/− mice. Expression of NGF and COX-2 mRNA was significantly increased 3 h after LC in all genotypes. However, GDNF mRNA did not increase in TRPV4−/− mice. These results suggest that TRPV1 contributes to DOMS downstream (possibly at nociceptors) of NGF and GDNF, while TRPV4 is located downstream of GDNF and possibly also in the process of GDNF up-regulation." @default.
• W2003205330 created "2016-06-24" @default.
• W2003205330 creator A5016247661 @default.
• W2003205330 creator A5031743010 @default.
• W2003205330 creator A5048937154 @default.
• W2003205330 creator A5054635423 @default.
• W2003205330 creator A5056529183 @default.
• W2003205330 creator A5074653699 @default.
• W2003205330 date "2013-06-17" @default.
• W2003205330 modified "2023-10-18" @default.
• W2003205330 title "TRPV1 and TRPV4 Play Pivotal Roles in Delayed Onset Muscle Soreness" @default.
• W2003205330 cites W1495409864 @default.
• W2003205330 cites W1502599914 @default.
• W2003205330 cites W1505133698 @default.
• W2003205330 cites W1511198581 @default.
• W2003205330 cites W1632948945 @default.
• W2003205330 cites W1817439804 @default.
• W2003205330 cites W1824181778 @default.
• W2003205330 cites W1965779217 @default.
• W2003205330 cites W1970629236 @default.
• W2003205330 cites W1974511772 @default.
• W2003205330 cites W1975177639 @default.
• W2003205330 cites W1975854407 @default.
• W2003205330 cites W1979759042 @default.
• W2003205330 cites W1984096754 @default.
• W2003205330 cites W1984928802 @default.
• W2003205330 cites W1985397070 @default.
• W2003205330 cites W1987772350 @default.
• W2003205330 cites W1995330222 @default.
• W2003205330 cites W1999333086 @default.
• W2003205330 cites W2009967312 @default.
• W2003205330 cites W2011557706 @default.
• W2003205330 cites W2014874693 @default.
• W2003205330 cites W2022167707 @default.
• W2003205330 cites W2023314433 @default.
• W2003205330 cites W2023865586 @default.
• W2003205330 cites W2023966975 @default.
• W2003205330 cites W2039249959 @default.
• W2003205330 cites W2039403600 @default.
• W2003205330 cites W2040501484 @default.
• W2003205330 cites W2041162116 @default.
• W2003205330 cites W2041940817 @default.
• W2003205330 cites W2042465203 @default.
• W2003205330 cites W2048041839 @default.
• W2003205330 cites W2049100687 @default.
• W2003205330 cites W2054154138 @default.
• W2003205330 cites W2069718130 @default.
• W2003205330 cites W2070056663 @default.
• W2003205330 cites W2071554097 @default.
• W2003205330 cites W2071595010 @default.
• W2003205330 cites W2077950886 @default.
• W2003205330 cites W2083562636 @default.
• W2003205330 cites W2087008579 @default.
• W2003205330 cites W2088885861 @default.
• W2003205330 cites W2090614803 @default.
• W2003205330 cites W2091396511 @default.
• W2003205330 cites W2094010226 @default.
• W2003205330 cites W2096773815 @default.
• W2003205330 cites W2100241249 @default.
• W2003205330 cites W2104764277 @default.
• W2003205330 cites W2106385852 @default.
• W2003205330 cites W2107705149 @default.
• W2003205330 cites W2107988902 @default.
• W2003205330 cites W2111569821 @default.
• W2003205330 cites W2113567556 @default.
• W2003205330 cites W2115607358 @default.
• W2003205330 cites W2118622904 @default.
• W2003205330 cites W2121725702 @default.
• W2003205330 cites W2128158693 @default.
• W2003205330 cites W2142230612 @default.
• W2003205330 cites W2145403417 @default.
• W2003205330 cites W2146252487 @default.
• W2003205330 cites W2149226420 @default.
• W2003205330 cites W2158621657 @default.
• W2003205330 cites W2160980017 @default.
• W2003205330 cites W4293222920 @default.
• W2003205330 doi "https://doi.org/10.1371/journal.pone.0065751" @default.
• W2003205330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3684597" @default.
• W2003205330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23799042" @default.
• W2003205330 hasPublicationYear "2013" @default.
• W2003205330 type Work @default.
• W2003205330 sameAs 2003205330 @default.
• W2003205330 citedByCount "51" @default.
• W2003205330 countsByYear W20032053302013 @default.
• W2003205330 countsByYear W20032053302014 @default.
• W2003205330 countsByYear W20032053302015 @default.
• W2003205330 countsByYear W20032053302016 @default.
• W2003205330 countsByYear W20032053302017 @default.
• W2003205330 countsByYear W20032053302018 @default.
• W2003205330 countsByYear W20032053302019 @default.
• W2003205330 countsByYear W20032053302020 @default.
• W2003205330 countsByYear W20032053302021 @default.
• W2003205330 countsByYear W20032053302022 @default.
• W2003205330 countsByYear W20032053302023 @default.
• W2003205330 crossrefType "journal-article" @default.
• W2003205330 hasAuthorship W2003205330A5016247661 @default.
• W2003205330 hasAuthorship W2003205330A5031743010 @default.
• W2003205330 hasAuthorship W2003205330A5048937154 @default.

• next