Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003208001> ?p ?o ?g. }
- W2003208001 endingPage "494" @default.
- W2003208001 startingPage "484" @default.
- W2003208001 abstract "HIV can rapidly evolve when placed under selective pressure, including immune surveillance or the administration of antiretroviral drugs. Typically, a variant protein allows HIV to directly evade the selective pressure. Similarly, HIV has escaped suppression by RNA interference (RNAi) directed against viral RNAs by acquiring mutations at the target region that circumvent RNAi-mediated inhibition while conserving necessary viral functions. However, when we directed RNAi against the viral TAR hairpin, which plays an indispensable role in viral transcription, resistant strains were recovered, but none carried a mutation at the target site. Instead, we isolated several strains carrying promoter mutations that indirectly compensated for the RNAi by upregulating viral transcription. Combining RNAi with the application of an antiviral drug blocked replication of such mutants. Evolutionary tuning of viral transcriptional regulation may serve as a general evasion mechanism that may be targeted to improve the efficacy of antiviral therapy." @default.
- W2003208001 created "2016-06-24" @default.
- W2003208001 creator A5002852323 @default.
- W2003208001 creator A5013729741 @default.
- W2003208001 creator A5033024988 @default.
- W2003208001 creator A5057179630 @default.
- W2003208001 date "2008-11-01" @default.
- W2003208001 modified "2023-09-27" @default.
- W2003208001 title "HIV Evades RNA Interference Directed at TAR by an Indirect Compensatory Mechanism" @default.
- W2003208001 cites W1613477799 @default.
- W2003208001 cites W1784634083 @default.
- W2003208001 cites W1835972708 @default.
- W2003208001 cites W1938941047 @default.
- W2003208001 cites W1956613412 @default.
- W2003208001 cites W1974756832 @default.
- W2003208001 cites W1974861468 @default.
- W2003208001 cites W1978539107 @default.
- W2003208001 cites W1983100586 @default.
- W2003208001 cites W1984064054 @default.
- W2003208001 cites W1988734689 @default.
- W2003208001 cites W1990636994 @default.
- W2003208001 cites W1993562443 @default.
- W2003208001 cites W1996443011 @default.
- W2003208001 cites W1998090661 @default.
- W2003208001 cites W1999477205 @default.
- W2003208001 cites W2001113321 @default.
- W2003208001 cites W2004552934 @default.
- W2003208001 cites W2006765654 @default.
- W2003208001 cites W2011879414 @default.
- W2003208001 cites W2022098233 @default.
- W2003208001 cites W2025678021 @default.
- W2003208001 cites W2030588812 @default.
- W2003208001 cites W2032235371 @default.
- W2003208001 cites W2034488184 @default.
- W2003208001 cites W2036108278 @default.
- W2003208001 cites W2036370282 @default.
- W2003208001 cites W2037067282 @default.
- W2003208001 cites W2037140037 @default.
- W2003208001 cites W2041375942 @default.
- W2003208001 cites W2050066317 @default.
- W2003208001 cites W2061113358 @default.
- W2003208001 cites W2062019922 @default.
- W2003208001 cites W2064557078 @default.
- W2003208001 cites W2064743809 @default.
- W2003208001 cites W2069608350 @default.
- W2003208001 cites W2069761065 @default.
- W2003208001 cites W2072916562 @default.
- W2003208001 cites W2072958095 @default.
- W2003208001 cites W2077088013 @default.
- W2003208001 cites W2079707100 @default.
- W2003208001 cites W2080237955 @default.
- W2003208001 cites W2086765669 @default.
- W2003208001 cites W2088493593 @default.
- W2003208001 cites W2102377924 @default.
- W2003208001 cites W2106448245 @default.
- W2003208001 cites W2107235611 @default.
- W2003208001 cites W2107277218 @default.
- W2003208001 cites W2108573975 @default.
- W2003208001 cites W2108595865 @default.
- W2003208001 cites W2108860228 @default.
- W2003208001 cites W2113210499 @default.
- W2003208001 cites W2116930183 @default.
- W2003208001 cites W2117185636 @default.
- W2003208001 cites W2129870871 @default.
- W2003208001 cites W2135135539 @default.
- W2003208001 cites W2140091023 @default.
- W2003208001 cites W2141157874 @default.
- W2003208001 cites W2144413761 @default.
- W2003208001 cites W2154947655 @default.
- W2003208001 cites W2162714406 @default.
- W2003208001 cites W2166329605 @default.
- W2003208001 cites W2170548736 @default.
- W2003208001 cites W2171228793 @default.
- W2003208001 cites W2192080449 @default.
- W2003208001 cites W4254038279 @default.
- W2003208001 cites W4321428183 @default.
- W2003208001 doi "https://doi.org/10.1016/j.chom.2008.09.008" @default.
- W2003208001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2742160" @default.
- W2003208001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18996348" @default.
- W2003208001 hasPublicationYear "2008" @default.
- W2003208001 type Work @default.
- W2003208001 sameAs 2003208001 @default.
- W2003208001 citedByCount "40" @default.
- W2003208001 countsByYear W20032080012012 @default.
- W2003208001 countsByYear W20032080012013 @default.
- W2003208001 countsByYear W20032080012014 @default.
- W2003208001 countsByYear W20032080012015 @default.
- W2003208001 countsByYear W20032080012016 @default.
- W2003208001 countsByYear W20032080012018 @default.
- W2003208001 countsByYear W20032080012022 @default.
- W2003208001 crossrefType "journal-article" @default.
- W2003208001 hasAuthorship W2003208001A5002852323 @default.
- W2003208001 hasAuthorship W2003208001A5013729741 @default.
- W2003208001 hasAuthorship W2003208001A5033024988 @default.
- W2003208001 hasAuthorship W2003208001A5057179630 @default.
- W2003208001 hasBestOaLocation W20032080011 @default.
- W2003208001 hasConcept C104317684 @default.
- W2003208001 hasConcept C111472728 @default.