Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003208348> ?p ?o ?g. }
- W2003208348 endingPage "e5822" @default.
- W2003208348 startingPage "e5822" @default.
- W2003208348 abstract "Recent studies have demonstrated a role for Staphylococcus aureus cidA-mediated cell lysis and genomic DNA release in biofilm adherence. The current study extends these findings by examining both temporal and additional genetic factors involved in the control of genomic DNA release and degradation during biofilm maturation. Cell lysis and DNA release were found to be critical for biofilm attachment during the initial stages of development and the released DNA (eDNA) remained an important matrix component during biofilm maturation. This study also revealed that an lrgAB mutant exhibits increased biofilm adherence and matrix-associated eDNA consistent with its proposed role as an inhibitor of cidA-mediated lysis. In flow-cell assays, both cid and lrg mutations had dramatic effects on biofilm maturation and tower formation. Finally, staphylococcal thermonuclease was shown to be involved in biofilm development as a nuc mutant formed a thicker biofilm containing increased levels of matrix-associated eDNA. Together, these findings suggest a model in which the opposing activities of the cid and lrg gene products control cell lysis and genomic DNA release during biofilm development, while staphylococcal thermonuclease functions to degrade the eDNA, possibly as a means to promote biofilm dispersal." @default.
- W2003208348 created "2016-06-24" @default.
- W2003208348 creator A5005469644 @default.
- W2003208348 creator A5045245130 @default.
- W2003208348 creator A5045569473 @default.
- W2003208348 creator A5048881547 @default.
- W2003208348 creator A5049789683 @default.
- W2003208348 creator A5057466810 @default.
- W2003208348 creator A5064607654 @default.
- W2003208348 creator A5075031124 @default.
- W2003208348 creator A5085741336 @default.
- W2003208348 creator A5089324530 @default.
- W2003208348 date "2009-06-09" @default.
- W2003208348 modified "2023-10-03" @default.
- W2003208348 title "Modulation of eDNA Release and Degradation Affects Staphylococcus aureus Biofilm Maturation" @default.
- W2003208348 cites W1508749862 @default.
- W2003208348 cites W1530112701 @default.
- W2003208348 cites W1560024199 @default.
- W2003208348 cites W1665252985 @default.
- W2003208348 cites W1967377218 @default.
- W2003208348 cites W1977185829 @default.
- W2003208348 cites W1980618604 @default.
- W2003208348 cites W1981804299 @default.
- W2003208348 cites W1987400078 @default.
- W2003208348 cites W1996442931 @default.
- W2003208348 cites W2001064516 @default.
- W2003208348 cites W2001760607 @default.
- W2003208348 cites W2005265983 @default.
- W2003208348 cites W2026220836 @default.
- W2003208348 cites W2040626723 @default.
- W2003208348 cites W2043346930 @default.
- W2003208348 cites W2053460725 @default.
- W2003208348 cites W2061688904 @default.
- W2003208348 cites W2062691302 @default.
- W2003208348 cites W2068871316 @default.
- W2003208348 cites W2076519023 @default.
- W2003208348 cites W2082900223 @default.
- W2003208348 cites W2084622748 @default.
- W2003208348 cites W2092553992 @default.
- W2003208348 cites W2096973732 @default.
- W2003208348 cites W2101293576 @default.
- W2003208348 cites W2102252790 @default.
- W2003208348 cites W2120160920 @default.
- W2003208348 cites W2127498551 @default.
- W2003208348 cites W2128139766 @default.
- W2003208348 cites W2131514331 @default.
- W2003208348 cites W2132160957 @default.
- W2003208348 cites W2132417094 @default.
- W2003208348 cites W2134515577 @default.
- W2003208348 cites W2135666698 @default.
- W2003208348 cites W2136459384 @default.
- W2003208348 cites W2137670228 @default.
- W2003208348 cites W2138502991 @default.
- W2003208348 cites W2145845793 @default.
- W2003208348 cites W2150907717 @default.
- W2003208348 cites W2153453937 @default.
- W2003208348 cites W2154135380 @default.
- W2003208348 cites W2155327463 @default.
- W2003208348 cites W2155708357 @default.
- W2003208348 cites W2156382695 @default.
- W2003208348 cites W2156879228 @default.
- W2003208348 cites W2162335168 @default.
- W2003208348 cites W2167240777 @default.
- W2003208348 cites W2172156934 @default.
- W2003208348 cites W2398137828 @default.
- W2003208348 doi "https://doi.org/10.1371/journal.pone.0005822" @default.
- W2003208348 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2688759" @default.
- W2003208348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19513119" @default.
- W2003208348 hasPublicationYear "2009" @default.
- W2003208348 type Work @default.
- W2003208348 sameAs 2003208348 @default.
- W2003208348 citedByCount "414" @default.
- W2003208348 countsByYear W20032083482012 @default.
- W2003208348 countsByYear W20032083482013 @default.
- W2003208348 countsByYear W20032083482014 @default.
- W2003208348 countsByYear W20032083482015 @default.
- W2003208348 countsByYear W20032083482016 @default.
- W2003208348 countsByYear W20032083482017 @default.
- W2003208348 countsByYear W20032083482018 @default.
- W2003208348 countsByYear W20032083482019 @default.
- W2003208348 countsByYear W20032083482020 @default.
- W2003208348 countsByYear W20032083482021 @default.
- W2003208348 countsByYear W20032083482022 @default.
- W2003208348 countsByYear W20032083482023 @default.
- W2003208348 crossrefType "journal-article" @default.
- W2003208348 hasAuthorship W2003208348A5005469644 @default.
- W2003208348 hasAuthorship W2003208348A5045245130 @default.
- W2003208348 hasAuthorship W2003208348A5045569473 @default.
- W2003208348 hasAuthorship W2003208348A5048881547 @default.
- W2003208348 hasAuthorship W2003208348A5049789683 @default.
- W2003208348 hasAuthorship W2003208348A5057466810 @default.
- W2003208348 hasAuthorship W2003208348A5064607654 @default.
- W2003208348 hasAuthorship W2003208348A5075031124 @default.
- W2003208348 hasAuthorship W2003208348A5085741336 @default.
- W2003208348 hasAuthorship W2003208348A5089324530 @default.
- W2003208348 hasBestOaLocation W20032083481 @default.
- W2003208348 hasConcept C104317684 @default.
- W2003208348 hasConcept C106487976 @default.