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• W2003209413 endingPage "52" @default.
• W2003209413 startingPage "43" @default.
• W2003209413 abstract "Abstract Treatment of Helicobacter pylori ( H. pylori ) infection has become a key factor in the management of dyspepsia and is the treatment of choice for peptic ulcer disease. First‐line eradication regimens combining a proton pump inhibitor (PPI) with clarithromycin and amoxicillin or metronidazole are considered most effective when given for a minimum period of 1 week. Eradication regimens of shorter duration have shown promising results but clinical experience remains limited. Pharmacological properties such as bioavailability and plasma concentrations of individual PPIs differ between individuals but it remains unclear whether these differences impact on the efficacy of eradication therapy and are influenced by renal or hepatic impairment. Bioavailability of PPIs also differs and is impacted on by factors including intragastric pH, metabolic pathways, potency on an mg‐for‐mg basis and intrinsic antibacterial activity. Several significant pharmacokinetic differences between the PPIs do not seem to influence overall H. pylori eradication rates for first‐line triple therapy. However, comparison of factors including pharmacokinetics and treatment duration may prove important in achieving successful eradication with second‐ and third‐line treatments. Based on the factors which influence therapy outcome, we suggest an algorithm for the use of H. pylori eradication therapies." @default.
• W2003209413 created "2016-06-24" @default.
• W2003209413 creator A5006488432 @default.
• W2003209413 creator A5061834547 @default.
• W2003209413 creator A5077320760 @default.
• W2003209413 date "2009-02-01" @default.
• W2003209413 modified "2023-10-16" @default.
• W2003209413 title "<i>Helicobacter pylori</i>eradication: role of individual therapy constituents and therapy duration" @default.
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• W2003209413 doi "https://doi.org/10.1111/j.1472-8206.2008.00635.x" @default.
• W2003209413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19207543" @default.

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