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- W2003213410 abstract "Alzheimer's disease (AD) is characterized by increased loss of synapses and decreased synaptic functioning. Fortasyn® Connect (FC) is a specific nutrient combination designed to target synaptic dysfunction in AD. Synapses consist principally of neuronal membranes of which phospholipids are the principal components. The present study was undertaken to investigate whether chronic dietary supplementation with FC enhances the formation and function of synaptic membranes in aged rats. Eighteen month-old male Wistar rats were randomized to Control and FC diet groups; rats in the Control group were supplemented with regular rat chow for 4 weeks while rats in the FC group were fed the FC diet for either 4 or 6 weeks. At end of dietary treatments, in vivo microdialysis was performed in the right hippocampus of rats in each group with or without atropine stimulation. On completion of microdialysis, rats were sacrificed and left hippocampi were obtained for analyses of phospholipid, synaptic protein, and choline acetyltransferase (ChAT) levels. Dietary treatment of aged rats with FC diet for 4 or 6 weeks significantly enhanced hippocampal acetylcholine levels and release, as well as the levels of total and major individual phospholipids. Supplementation with FC diet for 6 weeks significantly increased the levels of ChAT, as well as the pre- and post-synaptic markers, Synapsin-1 and PSD95, respectively. We conclude that chronic treatment with FC diet enhances hippocampal phospholipid levels in aged rats. FC diet treatment also increases levels of specific pre- and post-synaptic proteins, suggesting an enhancement in synaptic membranes. In addition, chronic supplementation with FC diet enhances synaptic function as evidenced by enhanced acetylcholine release. The present data provide further insight into cellular and molecular mechanisms by which the medical food Souvenaid®, containing FC, may improve memory as shown in patients with early AD." @default.
- W2003213410 created "2016-06-24" @default.
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- W2003213410 date "2013-07-01" @default.
- W2003213410 modified "2023-09-27" @default.
- W2003213410 title "P4-273: Fortasyn® Connect enhances synaptic membrane formation and function in the hippocampus of aged rats" @default.
- W2003213410 doi "https://doi.org/10.1016/j.jalz.2013.05.1666" @default.
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