FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003213669> ?p ?o ?g. }

• W2003213669 endingPage "806" @default.
• W2003213669 startingPage "797" @default.
• W2003213669 abstract "Metal salts can inhibit cell activity through direct toxicity to critical cellular molecules and structures. On the other hand, they can also change cell behaviour by inducing specific genes (including genes encoding members of the metallothionein [MT] gene family). Therefore, transition metals may affect cell functions either by acting as a toxin, or by transmitting or influencing signals controlling gene expression. To explore the latter possibility, we measured the ability of low, non-toxic metal pretreatment to alter immune cell behaviour. We previously found that pretreatment of human monocytes with zinc induces metallothionein gene expression and alters their capacity to undergo a bacterial lipopolysaccharide-induced respiratory burst. We showed here that cadmium and mercury salts, at concentrations that exert no discernible toxicity, inhibit activation of human monocytic leukemia (THP-1) cells. CdCl2 1 μm, ZnCl2 20–40 μm or HgCl2 2 μm pretreatment for 20 h induced MT-2 mRNA and total MT protein accumulation and had no effect on proliferation potential or metabolic activity, but significantly inhibited the ability of subsequent lipopolysaccharide treatment to induce the oxidative burst, increased adhesion to plastic, and MT-2 and interleukin-1β (IL-1β) mRNA accumulation. The phenomenon of metal-induced suppression of monocyte activation, at metal concentrations that have no effect on cell viability, has important implications for assessment of acceptable levels of human exposure to cadmium, zinc and mercury. British Journal of Pharmacology (1997) 120, 797–806; doi:10.1038/sj.bjp.0700975" @default.
• W2003213669 created "2016-06-24" @default.
• W2003213669 creator A5008902550 @default.
• W2003213669 creator A5060737195 @default.
• W2003213669 date "1997-02-01" @default.
• W2003213669 modified "2023-09-23" @default.
• W2003213669 title "Effect of non-toxic mercury, zinc or cadmium pretreatment on the capacity of human monocytes to undergo lipopolysaccharide-induced activation" @default.
• W2003213669 cites W1540228280 @default.
• W2003213669 cites W1545900640 @default.
• W2003213669 cites W1564328851 @default.
• W2003213669 cites W1594686929 @default.
• W2003213669 cites W175818448 @default.
• W2003213669 cites W1778601407 @default.
• W2003213669 cites W1833690096 @default.
• W2003213669 cites W1957208464 @default.
• W2003213669 cites W1965919540 @default.
• W2003213669 cites W1967004332 @default.
• W2003213669 cites W1968770520 @default.
• W2003213669 cites W1979433399 @default.
• W2003213669 cites W1980521223 @default.
• W2003213669 cites W1981163610 @default.
• W2003213669 cites W1991109223 @default.
• W2003213669 cites W1993359545 @default.
• W2003213669 cites W2000357041 @default.
• W2003213669 cites W2009696087 @default.
• W2003213669 cites W2013228603 @default.
• W2003213669 cites W2020163158 @default.
• W2003213669 cites W2032458072 @default.
• W2003213669 cites W2038398469 @default.
• W2003213669 cites W2045281985 @default.
• W2003213669 cites W2045300018 @default.
• W2003213669 cites W2048132363 @default.
• W2003213669 cites W2048369943 @default.
• W2003213669 cites W2051951087 @default.
• W2003213669 cites W2053572603 @default.
• W2003213669 cites W2053869868 @default.
• W2003213669 cites W2056206916 @default.
• W2003213669 cites W2056331361 @default.
• W2003213669 cites W2071567957 @default.
• W2003213669 cites W2073450079 @default.
• W2003213669 cites W2076317340 @default.
• W2003213669 cites W2076790289 @default.
• W2003213669 cites W2079115107 @default.
• W2003213669 cites W2081365941 @default.
• W2003213669 cites W2082247081 @default.
• W2003213669 cites W2082433177 @default.
• W2003213669 cites W2086524338 @default.
• W2003213669 cites W2087730469 @default.
• W2003213669 cites W2107442743 @default.
• W2003213669 cites W2132656334 @default.
• W2003213669 cites W2148259116 @default.
• W2003213669 cites W2154685249 @default.
• W2003213669 cites W2155142285 @default.
• W2003213669 cites W2232086804 @default.
• W2003213669 cites W2479856712 @default.
• W2003213669 cites W2500202773 @default.
• W2003213669 cites W2576734941 @default.
• W2003213669 cites W351515887 @default.
• W2003213669 cites W4293247451 @default.
• W2003213669 cites W5401597 @default.
• W2003213669 cites W54619079 @default.
• W2003213669 doi "https://doi.org/10.1038/sj.bjp.0700975" @default.
• W2003213669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1564538" @default.
• W2003213669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9138684" @default.
• W2003213669 hasPublicationYear "1997" @default.
• W2003213669 type Work @default.
• W2003213669 sameAs 2003213669 @default.
• W2003213669 citedByCount "49" @default.
• W2003213669 countsByYear W20032136692012 @default.
• W2003213669 countsByYear W20032136692014 @default.
• W2003213669 countsByYear W20032136692015 @default.
• W2003213669 countsByYear W20032136692016 @default.
• W2003213669 countsByYear W20032136692018 @default.
• W2003213669 countsByYear W20032136692019 @default.
• W2003213669 crossrefType "journal-article" @default.
• W2003213669 hasAuthorship W2003213669A5008902550 @default.
• W2003213669 hasAuthorship W2003213669A5060737195 @default.
• W2003213669 hasBestOaLocation W20032136692 @default.
• W2003213669 hasConcept C104317684 @default.
• W2003213669 hasConcept C150194340 @default.
• W2003213669 hasConcept C153911025 @default.
• W2003213669 hasConcept C178790620 @default.
• W2003213669 hasConcept C185592680 @default.
• W2003213669 hasConcept C203014093 @default.
• W2003213669 hasConcept C20719415 @default.
• W2003213669 hasConcept C2778754761 @default.
• W2003213669 hasConcept C2781184567 @default.
• W2003213669 hasConcept C29730261 @default.
• W2003213669 hasConcept C535196362 @default.
• W2003213669 hasConcept C544657597 @default.
• W2003213669 hasConcept C55493867 @default.
• W2003213669 hasConcept C86803240 @default.
• W2003213669 hasConcept C95444343 @default.
• W2003213669 hasConceptScore W2003213669C104317684 @default.
• W2003213669 hasConceptScore W2003213669C150194340 @default.
• W2003213669 hasConceptScore W2003213669C153911025 @default.
• W2003213669 hasConceptScore W2003213669C178790620 @default.
• W2003213669 hasConceptScore W2003213669C185592680 @default.

• next