Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003215093> ?p ?o ?g. }
- W2003215093 endingPage "1625" @default.
- W2003215093 startingPage "1625" @default.
- W2003215093 abstract "Beta-adrenoceptors (ARs), members of the G protein-coupled receptor (GPCR) superfamily, play a key role in the rapid regulation of myocardial function. Meanwhile, chronic catecholamine stimulation of adrenoceptors has been proved to be involved in the adverse myocardial remodeling, including cardiac hypertrophy, fibrosis, and apoptosis, which finally develop into heart failure. In the clinical situation, sympathetic hyperactivity is a key factor in the development of heart failure, and beta-blockers greatly improve the outcome of the disease. However, heart failure is still one of the leading causes of death. Therefore, a full understanding of the mechanism of beta-AR-mediated cardiac remodeling could indicate more targets for treating heart failure. This review summarizes a number of important signaling pathways involved in the process of cardiac pathological remodeling under chronic adrenergic stimulation." @default.
- W2003215093 created "2016-06-24" @default.
- W2003215093 creator A5022244258 @default.
- W2003215093 creator A5056917559 @default.
- W2003215093 creator A5062000735 @default.
- W2003215093 date "2012-01-01" @default.
- W2003215093 modified "2023-10-14" @default.
- W2003215093 title "Beta-adrenoceptor signaling pathways mediate cardiac pathological remodeling" @default.
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