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• W2003217557 abstract "Mutations in the Drosophila genes pimples and three rows result in a defect of sister chromatid separation during mitosis. As a consequence, cytokinesis is also defective. However, cell cycle progression including the mitotic degradation of cyclins A and B is not blocked by the failure of sister chromatid separation, and as a result, metaphase chromosomes with twice the normal number of chromosome arms still connected in the centromeric region are observed in the following mitosis, pimples encodes a novel protein that is rapidly degraded in mitosis. Our observations suggest that Pimples and Three rows act during mitosis to release the cohesion between sister centromeres." @default.
• W2003217557 created "2016-06-24" @default.
• W2003217557 creator A5023032903 @default.
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• W2003217557 date "1996-01-01" @default.
• W2003217557 modified "2023-09-25" @default.
• W2003217557 title "Separation of Sister Chromatids in Mitosis Requires the Drosophila pimples Product, a Protein Degraded after the Metaphase/Anaphase Transition" @default.
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• W2003217557 doi "https://doi.org/10.1016/s0092-8674(00)80990-3" @default.
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