FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003218087> ?p ?o ?g. }

• W2003218087 endingPage "214" @default.
• W2003218087 startingPage "181" @default.
• W2003218087 abstract "1. Double-pulse facilitation of Ca2+ channel currents in enzymatically dispersed adult rat superior cervical ganglion neurones was investigated using the whole-cell variant of the patch-clamp technique. Voltage-clamp recordings were performed at room temperature (21-24 degrees C) in solutions designed to isolate Ca2+ channel currents. 2. Ba2+ currents, elicited by a 0 mV test pulse, were increased in amplitude when preceded by a 40 ms pulse to voltages greater than 0 mV. The magnitude of facilitation was dependent on pre-pulse voltage and reached a maximum of 50% (i.e. 1.5 x the current amplitude elicited without a pre-pulse) at a pre-pulse voltage of +80 mV. Half-maximal facilitation occurred at about +25 mV. A small decrease (-6%) in test pulse amplitude was present at pre-pulse voltages between -40 and 0 mV. The magnitude of facilitation was also dependent on test pulse voltage. Facilitation was greatest between test pulse voltages of -10 and 0 mV. 3. Facilitation slowly decreased during prolonged (1 h) dialysis of the neurone even though the Ba2+ current amplitude was well maintained. 4. Increasing the pre-pulse duration over the range 0-120 ms produced an exponential increase in facilitation with a time constant of 17.3 ms. Conversely, lengthening the interpulse duration over the range 5-915 ms, while maintaining a constant pre-pulse amplitude and duration, resulted in an exponential decrease in facilitation with a time constant of 197 ms. 5. At a test potential of 0 mV, the decay of the facilitated Ba2+ current component was fitted to a double exponential function with time constants of about 25 and 150 ms. The time constants had little pre-pulse voltage dependence between +30 to +80 mV. 6. The initial rising phase of both the control and facilitated Ba2+ current were reasonably well described by a single exponential (tau rise) after a delay of 300 microseconds. The tau rise versus test pulse potential relationship was ‘bell shaped’ over the test pulse voltage of -20 to +30 mV reaching a maximum near -5 mV. tau rise was similar for control and facilitated currents except at potentials greater than +10 mV where the rise of the facilitated current was accelerated. 7. Control and facilitated activation curves, as derived from tail current amplitudes, were described by the sum of two Boltzmann functions. A facilitating pre-pulse produced an increase in the proportion of the current contributed by the component activated at more hyperpolarized test potentials.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2003218087 created "2016-06-24" @default.
• W2003218087 creator A5076023837 @default.
• W2003218087 date "1991-07-01" @default.
• W2003218087 modified "2023-10-11" @default.
• W2003218087 title "Double-pulse calcium channel current facilitation in adult rat sympathetic neurones." @default.
• W2003218087 cites W1504051397 @default.
• W2003218087 cites W1507549362 @default.
• W2003218087 cites W1533750627 @default.
• W2003218087 cites W1963510189 @default.
• W2003218087 cites W1964033248 @default.
• W2003218087 cites W1967812690 @default.
• W2003218087 cites W1968094290 @default.
• W2003218087 cites W1978319294 @default.
• W2003218087 cites W1979488623 @default.
• W2003218087 cites W1986144684 @default.
• W2003218087 cites W1996146661 @default.
• W2003218087 cites W1997511216 @default.
• W2003218087 cites W2001201602 @default.
• W2003218087 cites W2002740655 @default.
• W2003218087 cites W2005189737 @default.
• W2003218087 cites W2009667219 @default.
• W2003218087 cites W2015426350 @default.
• W2003218087 cites W2017653020 @default.
• W2003218087 cites W2020981141 @default.
• W2003218087 cites W2030740718 @default.
• W2003218087 cites W2033558463 @default.
• W2003218087 cites W2036324276 @default.
• W2003218087 cites W2046271917 @default.
• W2003218087 cites W2046764546 @default.
• W2003218087 cites W2047458497 @default.
• W2003218087 cites W2053559739 @default.
• W2003218087 cites W2055012870 @default.
• W2003218087 cites W2055096406 @default.
• W2003218087 cites W2058925305 @default.
• W2003218087 cites W2058987907 @default.
• W2003218087 cites W2060765203 @default.
• W2003218087 cites W2061056399 @default.
• W2003218087 cites W2064748241 @default.
• W2003218087 cites W2066352663 @default.
• W2003218087 cites W2067995523 @default.
• W2003218087 cites W2076794764 @default.
• W2003218087 cites W2078316320 @default.
• W2003218087 cites W2080530601 @default.
• W2003218087 cites W2080875376 @default.
• W2003218087 cites W2081623770 @default.
• W2003218087 cites W2083123532 @default.
• W2003218087 cites W2084544813 @default.
• W2003218087 cites W2087216042 @default.
• W2003218087 cites W2091188316 @default.
• W2003218087 cites W2121137104 @default.
• W2003218087 cites W2123591127 @default.
• W2003218087 cites W2155751245 @default.
• W2003218087 cites W2157121602 @default.
• W2003218087 cites W2170362617 @default.
• W2003218087 cites W2318256351 @default.
• W2003218087 cites W59864469 @default.
• W2003218087 doi "https://doi.org/10.1113/jphysiol.1991.sp018663" @default.
• W2003218087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1180105" @default.
• W2003218087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1654413" @default.
• W2003218087 hasPublicationYear "1991" @default.
• W2003218087 type Work @default.
• W2003218087 sameAs 2003218087 @default.
• W2003218087 citedByCount "242" @default.
• W2003218087 countsByYear W20032180872012 @default.
• W2003218087 countsByYear W20032180872013 @default.
• W2003218087 countsByYear W20032180872014 @default.
• W2003218087 countsByYear W20032180872015 @default.
• W2003218087 countsByYear W20032180872016 @default.
• W2003218087 countsByYear W20032180872020 @default.
• W2003218087 countsByYear W20032180872021 @default.
• W2003218087 countsByYear W20032180872022 @default.
• W2003218087 crossrefType "journal-article" @default.
• W2003218087 hasAuthorship W2003218087A5076023837 @default.
• W2003218087 hasBestOaLocation W20032180871 @default.
• W2003218087 hasConcept C119599485 @default.
• W2003218087 hasConcept C120665830 @default.
• W2003218087 hasConcept C121332964 @default.
• W2003218087 hasConcept C127413603 @default.
• W2003218087 hasConcept C1337776 @default.
• W2003218087 hasConcept C165801399 @default.
• W2003218087 hasConcept C169150495 @default.
• W2003218087 hasConcept C169760540 @default.
• W2003218087 hasConcept C170493617 @default.
• W2003218087 hasConcept C180205008 @default.
• W2003218087 hasConcept C185592680 @default.
• W2003218087 hasConcept C192562407 @default.
• W2003218087 hasConcept C200170125 @default.
• W2003218087 hasConcept C20518276 @default.
• W2003218087 hasConcept C2780167933 @default.
• W2003218087 hasConcept C29561615 @default.
• W2003218087 hasConcept C520434653 @default.
• W2003218087 hasConcept C55493867 @default.
• W2003218087 hasConcept C62520636 @default.
• W2003218087 hasConcept C81370116 @default.
• W2003218087 hasConcept C86803240 @default.
• W2003218087 hasConceptScore W2003218087C119599485 @default.
• W2003218087 hasConceptScore W2003218087C120665830 @default.

• next