FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003219097> ?p ?o ?g. }

• W2003219097 endingPage "217" @default.
• W2003219097 startingPage "210" @default.
• W2003219097 abstract "A key in understanding the neurobiology of addiction and developing effective pharmacotherapies is revealing drug-induced plasticity that results in heightened relapse susceptibility. Previous studies have demonstrated that increased extracellular glutamate, but not dopamine, in the nucleus accumbens core (NAcc) is necessary for cocaine-induced reinstatement. In this report, we examined whether drug-induced adaptations that are necessary to generate cocaine-induced reinstatement also determine relapse vulnerability. To do this, rats were assigned to self-administer cocaine under conditions resulting in low (2 h/d; 0.5 mg/kg/infusion, i.v.) or high (6 h/d; 1.0 mg/kg/infusion, i.v.) levels of drug intake since these manipulations produce groups of rats exhibiting differences in the magnitude of cocaine-induced reinstatement. Approximately 19 d after the last session, cocaine-induced drug seeking and extracellular levels of glutamate and dopamine in the NAcc were measured. Contrary to our hypothesis, high-intake rats exhibited a more robust cocaine-induced increase in extracellular levels of dopamine but not glutamate. Further, increased reinstatement in high-intake rats was no longer observed when the D(1) receptor antagonist SCH-23390 was infused into the NAcc. The sensitized dopamine response to cocaine in high-intake rats may involve blunted cystine-glutamate exchange by system x(c(-)). Reduced (14)C-cystine uptake through system x(c(-)) was evident in NAcc tissue slices obtained from high-intake rats, and the augmented dopamine response in these rats was no longer observed when subjects received the cysteine prodrug N-acetyl cysteine. These data reveal a role for drug-induced NAcc dopamine in heightened relapse vulnerability observed in rats with a history of high levels of drug intake." @default.
• W2003219097 created "2016-06-24" @default.
• W2003219097 creator A5027062572 @default.
• W2003219097 creator A5041383371 @default.
• W2003219097 creator A5051210209 @default.
• W2003219097 creator A5077757829 @default.
• W2003219097 creator A5091048537 @default.
• W2003219097 creator A5091237897 @default.
• W2003219097 date "2010-01-06" @default.
• W2003219097 modified "2023-09-27" @default.
• W2003219097 title "Drug-Induced Plasticity Contributing to Heightened Relapse Susceptibility: Neurochemical Changes and Augmented Reinstatement in High-Intake Rats" @default.
• W2003219097 cites W1480740183 @default.
• W2003219097 cites W1889428062 @default.
• W2003219097 cites W1902584234 @default.
• W2003219097 cites W1933207236 @default.
• W2003219097 cites W1967292256 @default.
• W2003219097 cites W1977349026 @default.
• W2003219097 cites W1978686840 @default.
• W2003219097 cites W1980932813 @default.
• W2003219097 cites W1993787748 @default.
• W2003219097 cites W1994701676 @default.
• W2003219097 cites W1995006074 @default.
• W2003219097 cites W1996702054 @default.
• W2003219097 cites W2000048861 @default.
• W2003219097 cites W2000825098 @default.
• W2003219097 cites W2002455556 @default.
• W2003219097 cites W2009752850 @default.
• W2003219097 cites W2023136242 @default.
• W2003219097 cites W2023761294 @default.
• W2003219097 cites W2030310872 @default.
• W2003219097 cites W2030391328 @default.
• W2003219097 cites W2036934626 @default.
• W2003219097 cites W2038064315 @default.
• W2003219097 cites W2045185962 @default.
• W2003219097 cites W2045731254 @default.
• W2003219097 cites W2054053664 @default.
• W2003219097 cites W2059164249 @default.
• W2003219097 cites W2067317040 @default.
• W2003219097 cites W2069294714 @default.
• W2003219097 cites W2075823677 @default.
• W2003219097 cites W2075863805 @default.
• W2003219097 cites W2079062881 @default.
• W2003219097 cites W2084434011 @default.
• W2003219097 cites W2087657646 @default.
• W2003219097 cites W2088991430 @default.
• W2003219097 cites W2089464278 @default.
• W2003219097 cites W2090078976 @default.
• W2003219097 cites W2090481799 @default.
• W2003219097 cites W2092106228 @default.
• W2003219097 cites W2093716510 @default.
• W2003219097 cites W2095219741 @default.
• W2003219097 cites W2103057436 @default.
• W2003219097 cites W2108849121 @default.
• W2003219097 cites W2123946759 @default.
• W2003219097 cites W2130332398 @default.
• W2003219097 cites W4247903799 @default.
• W2003219097 cites W4317929355 @default.
• W2003219097 doi "https://doi.org/10.1523/jneurosci.1342-09.2010" @default.
• W2003219097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2823262" @default.
• W2003219097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20053903" @default.
• W2003219097 hasPublicationYear "2010" @default.
• W2003219097 type Work @default.
• W2003219097 sameAs 2003219097 @default.
• W2003219097 citedByCount "33" @default.
• W2003219097 countsByYear W20032190972012 @default.
• W2003219097 countsByYear W20032190972013 @default.
• W2003219097 countsByYear W20032190972014 @default.
• W2003219097 countsByYear W20032190972015 @default.
• W2003219097 countsByYear W20032190972016 @default.
• W2003219097 countsByYear W20032190972017 @default.
• W2003219097 countsByYear W20032190972018 @default.
• W2003219097 countsByYear W20032190972019 @default.
• W2003219097 countsByYear W20032190972020 @default.
• W2003219097 countsByYear W20032190972021 @default.
• W2003219097 countsByYear W20032190972022 @default.
• W2003219097 countsByYear W20032190972023 @default.
• W2003219097 crossrefType "journal-article" @default.
• W2003219097 hasAuthorship W2003219097A5027062572 @default.
• W2003219097 hasAuthorship W2003219097A5041383371 @default.
• W2003219097 hasAuthorship W2003219097A5051210209 @default.
• W2003219097 hasAuthorship W2003219097A5077757829 @default.
• W2003219097 hasAuthorship W2003219097A5091048537 @default.
• W2003219097 hasAuthorship W2003219097A5091237897 @default.
• W2003219097 hasBestOaLocation W20032190971 @default.
• W2003219097 hasConcept C126322002 @default.
• W2003219097 hasConcept C134018914 @default.
• W2003219097 hasConcept C15744967 @default.
• W2003219097 hasConcept C169760540 @default.
• W2003219097 hasConcept C170493617 @default.
• W2003219097 hasConcept C185592680 @default.
• W2003219097 hasConcept C25876315 @default.
• W2003219097 hasConcept C2776552330 @default.
• W2003219097 hasConcept C2780557958 @default.
• W2003219097 hasConcept C28406088 @default.
• W2003219097 hasConcept C48856860 @default.
• W2003219097 hasConcept C513476851 @default.
• W2003219097 hasConcept C55493867 @default.
• W2003219097 hasConcept C61174792 @default.

• next