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- W2003222644 abstract "Mitochondrial DNA is a sensitive target of chemical carcinogens (Backer and Weinstein (1980) Science 209, 297-299), suggesting that mutations of the mitochondrial genome occur in tumor cells. We examined this point by comparing mitochondrial DNA sequences 1n four rat tumors with those of normal rat liver. Some novel mutations found in the tRNA genes of tumor mitochondria were as follows: nucleotides deletions in the aminoacy1 acceptor stem of the tRNA Typ gene or in the anticodon stem of the tRNA Tyr gene and insertions in the “TΨC” loop of the tRNA cys gene. These structures are extraordinary compared with those of the tRNA genes of other mammals, indicating that these mutations are each associated with a corresponding tumor." @default.
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- W2003222644 date "1983-01-01" @default.
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- W2003222644 title "Tumor-associated mutations of rat mitochondrial transfer RNA genes" @default.
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- W2003222644 doi "https://doi.org/10.1093/nar/11.6.1635" @default.
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