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- W2003225482 abstract "The nuclear vitamin D receptor (VDR) mediates the actions of its 1,25-dihydroxyvitamin D3 ligand to control gene expression in terrestrial vertebrates. Prominent functions of VDR-regulated genes are to promote intestinal absorption of calcium and phosphate for bone mineralization and to potentiate the hair cycle in mammals. We report the cloning of VDR from Petromyzon marinus, an unexpected finding because lampreys lack mineralized tissues and hair. Lamprey VDR (lampVDR) clones were obtained via RT-PCR from larval protospleen tissue and skin and mouth of juveniles. LampVDR expressed in transfected mammalian COS-7 cells bound 1,25-dihydroxyvitamin D3 with high affinity, and transactivated a reporter gene linked to a vitamin D-responsive element from the human CYP3A4 gene, which encodes a P450 enzyme involved in xenobiotic detoxification. In tests with other vitamin D responsive elements, such as that from the rat osteocalcin gene, lampVDR showed little or no activity. Phylogenetic comparisons with nuclear receptors from other vertebrates revealed that lampVDR is a basal member of the VDR grouping, also closely related to the pregnane X receptors and constitutive androstane receptors. We propose that, in this evolutionarily ancient vertebrate, VDR may function in part, like pregnane X receptors and constitutive androstane receptors, to induce P450 enzymes for xenobiotic detoxification." @default.
- W2003225482 created "2016-06-24" @default.
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- W2003225482 date "2003-06-01" @default.
- W2003225482 modified "2023-10-16" @default.
- W2003225482 title "Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth" @default.
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- W2003225482 cites W1970764506 @default.
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- W2003225482 cites W1985865142 @default.
- W2003225482 cites W1992847499 @default.
- W2003225482 cites W1995546675 @default.
- W2003225482 cites W1998861020 @default.
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- W2003225482 cites W2005704606 @default.
- W2003225482 cites W2005936777 @default.
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- W2003225482 cites W2021206718 @default.
- W2003225482 cites W2029475329 @default.
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- W2003225482 cites W2043813981 @default.
- W2003225482 cites W2045812196 @default.
- W2003225482 cites W2047681882 @default.
- W2003225482 cites W2048415171 @default.
- W2003225482 cites W2048782626 @default.
- W2003225482 cites W2052006868 @default.
- W2003225482 cites W2054548531 @default.
- W2003225482 cites W2064352058 @default.
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- W2003225482 cites W2071142567 @default.
- W2003225482 cites W2073870011 @default.
- W2003225482 cites W2074684677 @default.
- W2003225482 cites W2079080809 @default.
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- W2003225482 doi "https://doi.org/10.1210/en.2002-221101" @default.
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