Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003227805> ?p ?o ?g. }
- W2003227805 endingPage "596" @default.
- W2003227805 startingPage "587" @default.
- W2003227805 abstract "A significant portion of the world's population suffers from sporadic Alzheimer's disease (AD) with available present therapies limited to symptomatic care that does not alter disease progression. Over the next decade, advancing age of the global population will dramatically increase the incidence of AD and severely impact health care resources, necessitating novel, safe, and efficacious strategies for AD. The mammalian target of rapamycin (mTOR) and its protein complexes mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2) offer exciting and unique avenues of intervention for AD through the oversight of programmed cell death pathways of apoptosis, autophagy, and necroptosis. mTOR modulates multi-faceted signal transduction pathways that involve phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), hamartin (tuberous sclerosis 1)/ tuberin (tuberous sclerosis 2) (TSC1/TSC2) complex, proline-rich Akt substrate 40 kDa (PRAS40), and p70 ribosomal S6 kinase (p70S6K) and can interface with the neuroprotective pathways of growth factors, sirtuins, wingless, forkhead transcription factors, and glycogen synthase kinase-3β. With the ability of mTOR to broadly impact cellular function, clinical strategies for AD that implement mTOR must achieve parallel objectives of protecting neuronal, vascular, and immune cell survival in conjunction with preserving networks that determine memory and cognitive function." @default.
- W2003227805 created "2016-06-24" @default.
- W2003227805 creator A5000415542 @default.
- W2003227805 date "2014-08-08" @default.
- W2003227805 modified "2023-10-04" @default.
- W2003227805 title "Taking aim at Alzheimer's disease through the mammalian target of rapamycin" @default.
- W2003227805 cites W1509666005 @default.
- W2003227805 cites W1601336661 @default.
- W2003227805 cites W1670818389 @default.
- W2003227805 cites W1935457268 @default.
- W2003227805 cites W1938722649 @default.
- W2003227805 cites W1968962277 @default.
- W2003227805 cites W1973350681 @default.
- W2003227805 cites W1974034152 @default.
- W2003227805 cites W1974226776 @default.
- W2003227805 cites W1975223656 @default.
- W2003227805 cites W1977785446 @default.
- W2003227805 cites W1978599577 @default.
- W2003227805 cites W1980204153 @default.
- W2003227805 cites W1983698019 @default.
- W2003227805 cites W1986442348 @default.
- W2003227805 cites W1987186266 @default.
- W2003227805 cites W1987536543 @default.
- W2003227805 cites W1988772292 @default.
- W2003227805 cites W1992112841 @default.
- W2003227805 cites W1993642204 @default.
- W2003227805 cites W1993781471 @default.
- W2003227805 cites W1995391763 @default.
- W2003227805 cites W1995569466 @default.
- W2003227805 cites W1995576455 @default.
- W2003227805 cites W1997292668 @default.
- W2003227805 cites W1997996318 @default.
- W2003227805 cites W1999916995 @default.
- W2003227805 cites W2000464736 @default.
- W2003227805 cites W2000731858 @default.
- W2003227805 cites W2000873101 @default.
- W2003227805 cites W2002440118 @default.
- W2003227805 cites W2002833886 @default.
- W2003227805 cites W2003657436 @default.
- W2003227805 cites W2004131942 @default.
- W2003227805 cites W2007631668 @default.
- W2003227805 cites W2011134915 @default.
- W2003227805 cites W2011707975 @default.
- W2003227805 cites W2012153056 @default.
- W2003227805 cites W2013518349 @default.
- W2003227805 cites W2018247131 @default.
- W2003227805 cites W2019551003 @default.
- W2003227805 cites W2020777578 @default.
- W2003227805 cites W2021933220 @default.
- W2003227805 cites W2028628328 @default.
- W2003227805 cites W2029308011 @default.
- W2003227805 cites W2030270079 @default.
- W2003227805 cites W2031217161 @default.
- W2003227805 cites W2031507955 @default.
- W2003227805 cites W2034451927 @default.
- W2003227805 cites W2035495486 @default.
- W2003227805 cites W2037653131 @default.
- W2003227805 cites W2043214154 @default.
- W2003227805 cites W2043317203 @default.
- W2003227805 cites W2043912659 @default.
- W2003227805 cites W2047265153 @default.
- W2003227805 cites W2047374141 @default.
- W2003227805 cites W2047854832 @default.
- W2003227805 cites W2050697491 @default.
- W2003227805 cites W2051042258 @default.
- W2003227805 cites W2052117124 @default.
- W2003227805 cites W2052579653 @default.
- W2003227805 cites W2052859130 @default.
- W2003227805 cites W2054033084 @default.
- W2003227805 cites W2055701940 @default.
- W2003227805 cites W2056513212 @default.
- W2003227805 cites W2057827526 @default.
- W2003227805 cites W2059124041 @default.
- W2003227805 cites W2059387378 @default.
- W2003227805 cites W2060825427 @default.
- W2003227805 cites W2062195516 @default.
- W2003227805 cites W2063013559 @default.
- W2003227805 cites W2064438779 @default.
- W2003227805 cites W2064600058 @default.
- W2003227805 cites W2067152194 @default.
- W2003227805 cites W2071999004 @default.
- W2003227805 cites W2072534288 @default.
- W2003227805 cites W2073226327 @default.
- W2003227805 cites W2074176256 @default.
- W2003227805 cites W2074866669 @default.
- W2003227805 cites W2076501000 @default.
- W2003227805 cites W2076695125 @default.
- W2003227805 cites W2078207717 @default.
- W2003227805 cites W2079627863 @default.
- W2003227805 cites W2085895306 @default.
- W2003227805 cites W2092113256 @default.
- W2003227805 cites W2093579930 @default.
- W2003227805 cites W2095314609 @default.
- W2003227805 cites W2096068072 @default.
- W2003227805 cites W2097566177 @default.
- W2003227805 cites W2098375920 @default.
- W2003227805 cites W2099031084 @default.
- W2003227805 cites W2104267594 @default.