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- W2003231748 abstract "The metabolism of metoclopramide 1 has been re investigated by HPLC coupled with mass spectrometry. The urine of healthy volunteers showed the presence of a new metabolite 2 derived from the enzymatic oxidation of the primary aromatic amino group of 1 to the hydroxylamino moiety. The structure of the new metabolite was ascertained by its fragmentation pattern in the mass spectrometer and unambiguously secured by an independent synthesis. In addition, the tertiary amine group of 1 was selectively oxidized to the corresponding N-oxide. This compound and its ring oxidation metabolites were not detected in the urine of the tested volunteers." @default.
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- W2003231748 date "1995-01-01" @default.
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- W2003231748 title "Identification and full characterization of a new metabolite of metoclopramide" @default.
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- W2003231748 doi "https://doi.org/10.1016/0223-5234(96)88294-8" @default.
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