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- W2003232353 abstract "Dilated cardiomyopathy presenting during childhood carries a significant morbidity and mortality, but there is little published data on cases presenting prior to birth. We report a 20 year experience of dilated cardiomyopathy presenting to a tertiary fetal cardiology centre. Affected fetuses were identified using a computerised database. Fetuses with dilation and reduced systolic function of either the right ventricle, left ventricle or both, were included. 50 fetuses were identified, born to 46 mothers. 24 fetuses had biventricular cardiomyopathy, 17 had isolated right ventricular cardiomyopathy and 9 had isolated left ventricular cardiomyopathy. 32 (64%) fetuses were hydropic at some point during gestation. A cause of cardiomyopathy was identified in 37 cases (74%). These were genetic or metabolic in 11 fetuses, infection in 11, fetal anaemia (without proven Parvovirus infection) in 5, cardiac causes in 5 and renal causes in 5. Ten pregnancies (20%) resulted in termination of pregnancy. Based on an intention to treat, the survival to delivery was 25/40 (62.5%), at 28 days 17/40 (42.5%), and at one year 15/40 (37.5%). The overall survival of nonhydropic fetuses was 9/18 (50%) versus 6/32 (18%) for hydropic fetuses. Genetic, metabolic, infective and cardiac diseases may present with dilated cardiomyopathy during fetal life. There is a high rate of spontaneous intra-uterine and early neonatal death. The prognosis is particularly poor for hydropic fetuses." @default.
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- W2003232353 date "2004-08-01" @default.
- W2003232353 modified "2023-10-16" @default.
- W2003232353 title "P01.30: Dilated cardiomyopathy presenting during fetal life" @default.
- W2003232353 doi "https://doi.org/10.1002/uog.1336" @default.
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