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• W2003232767 abstract "Objective To evaluate the safety and efficacy of once-daily (QD) fluticasone furoate (FF) nasal spray in children with perennial allergic rhinitis (PAR). Study Design A global, randomized, double-blind, placebo-controlled study. Subjects and Methods Pediatric patients (aged 2–11 years; n = 558) with PAR received once-daily placebo, FF 110 μg, or FF 55 μg for 12 weeks. Efficacy was evaluated by nasal symptom scores. General safety and corticosteroid-specific safety (nasal and ophthalmic examinations, and hypothalamic—pituitary—adrenal assessments) were assessed. Results No findings of clinical concern were identified from the safety assessments. For primary efficacy analysis of mean change from baseline over the first 4 weeks of treatment in daily reflective total nasal symptom score, FF 55 μg demonstrated significant improvement ( P = 0.003) compared with placebo; however, the improvement for FF 110 μg versus placebo did not reach statistical significance ( P = 0.073). Conclusion FF QD was well tolerated and demonstrated efficacy in children aged 2 to 11 years with PAR." @default.
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• W2003232767 date "2008-01-01" @default.
• W2003232767 modified "2023-09-27" @default.
• W2003232767 title "Safety and efficacy of fluticasone furoate in pediatric patients with perennial allergic rhinitis" @default.
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• W2003232767 doi "https://doi.org/10.1016/j.otohns.2007.10.023" @default.
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