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- W2003233011 abstract "Glycyrrhiza uralensis (Leguminosae) has long been known as an antiinflammatory agent for gastric ulcers, arthritis, and rheumatism. The flavonoid glycyrol (GC) (10 μg/ml) isolated from G. uralensis dramatically inhibits phorbol ester (phorbol 12-myristate 13-acetate)-induced nuclear factor (NF)-κB-dependent transcriptional activity, as determined by luciferase reporter activity in human kidney epithelial 293T cells. To investigate global gene expression profiling in cells by GC, we performed high-density oligonucleotide microarrays. Our microarray analyses showed that GC inhibited phorbol ester-induced NF-κB-dependent transcriptional activity in inflammatory-related gene expression. RT-PCR analysis, based on microarray data, showed that NF-κB-dependent genes (such as CCL2, CCL7, CD44, and HSPB8 in addition to NF-κB itself) were significantly downregulated by GC. Treatment with GC (10 μg/ml) inhibited I-κB degradation induced by phorbol 12-myristate 13-acetate. The microarray data also suggested that GC induces gene expression to p53-dependent apoptosis through endonuclease G, instead of CAD/DFF and AIF/PDCD8, as a downstream-apoptosis factor in human kidney epithelial 293T tumor cells, and induces oncogenes with a suppressor role as an added function." @default.
- W2003233011 created "2016-06-24" @default.
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- W2003233011 date "2008-06-01" @default.
- W2003233011 modified "2023-10-02" @default.
- W2003233011 title "Gene induction by glycyrol to apoptosis through endonuclease G in tumor cells and prediction of oncogene function by microarray analysis" @default.
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- W2003233011 doi "https://doi.org/10.1097/cad.0b013e3282fba582" @default.
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