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• W2003233492 abstract "A series of acyloxyalkyl and amidooxyalkyl ketones appended to a carbobenzyloxy aspartic acid core have been prepared. The most potent of these new inhibitors was 4i with a K(i) of 0.5 microM. These two series provide an improved understanding of the binding requirements for the hydrophobic prime side of ICE." @default.
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• W2003233492 date "2010-09-01" @default.
• W2003233492 modified "2023-09-26" @default.
• W2003233492 title "Inhibition of interleukin-1β converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones" @default.
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• W2003233492 doi "https://doi.org/10.1016/j.bmcl.2010.07.031" @default.
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