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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003235012> ?p ?o ?g. }

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• W2003235012 abstract "The cellular introduction of short, interfering RNA leads to sequence-specific degradation of homologous mRNA, a process termed RNA interference (RNAi). Here, we report that recombinant adeno-associated virus 2 (rAAV-2) can be used to transfer short hairpin (sh) RNA expression cassettes genetically into human cells. HIV-1 replication was suppressed by >95% in H9 cells and primary human lymphocytes that expressed shRNA targeting the first exon of the viral transactivator protein tat compared to control cells. rAAV-2 integrated stably into the host genome, leading to long-term expression of tat shRNA. Our findings demonstrate the utility of rAAV-2 for the genetic transfer of shRNA expression cassettes into human cells, providing an alternative to using retroviral vectors as RNAi delivery systems." @default.
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• W2003235012 date "2004-03-01" @default.
• W2003235012 modified "2023-09-25" @default.
• W2003235012 title "Efficient Gene Transfer of HIV-1-Specific Short Hairpin RNA into Human Lymphocytic Cells Using Recombinant Adeno-associated Virus Vectors" @default.
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• W2003235012 doi "https://doi.org/10.1016/j.ymthe.2003.11.025" @default.
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