FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003235575> ?p ?o ?g. }

• W2003235575 abstract "Bipolar disorder is associated with significant morbidity and mortality; however, many aspects of this disorder remain poorly understood. It is likely that rapid advances in molecular genetics and neuroimaging will play a major role in advancing our understanding of bipolar disorder in future. Molecular genetics studies have already identified some candidate genes; for example, the BDNF, G72 and XBP1 genes, and chromosomal 'hot spots', which may confer a predisposition to development of bipolar disorder. Such advances may facilitate earlier, easier and more accurate diagnosis and provide novel targets for the treatment of this condition. Brain imaging studies using positron emission tomography and single photon emission computed tomography have shown that reduction in brain 5-hydroxytryptamine type 2 (5-HT(2)) receptors may be associated with prevention of or relief from depressive symptoms. Similarly, other imaging studies suggest that increased dopamine levels in the synapse mediate the symptoms of bipolar mania and that reduction in dopamine transmission through reduction in dopamine synthesis or blockade of dopamine D(2) receptors may be associated with antimanic effects. The ability of atypical antipsychotics to block both 5-HT(2) and D(2) receptors and downregulate 5-HT(2) receptors may explain how these drugs treat both the depressive and manic symptoms of bipolar disorder. Although molecular genetics and imaging techniques are not yet used as clinical tools for bipolar disorder, they provide valuable data to improve the understanding of the pathophysiology of bipolar disorder and should lead to new treatments and potentially episode prevention." @default.
• W2003235575 created "2016-06-24" @default.
• W2003235575 creator A5035147009 @default.
• W2003235575 date "2005-08-01" @default.
• W2003235575 modified "2023-09-25" @default.
• W2003235575 title "Translating knowledge of genetics and pharmacology into improving everyday practice" @default.
• W2003235575 cites W1512425680 @default.
• W2003235575 cites W1939097681 @default.
• W2003235575 cites W1979166893 @default.
• W2003235575 cites W1994197073 @default.
• W2003235575 cites W1998184647 @default.
• W2003235575 cites W1999046457 @default.
• W2003235575 cites W2005149816 @default.
• W2003235575 cites W2009203109 @default.
• W2003235575 cites W2016906176 @default.
• W2003235575 cites W2024299693 @default.
• W2003235575 cites W2024539842 @default.
• W2003235575 cites W2039391993 @default.
• W2003235575 cites W2057648859 @default.
• W2003235575 cites W2092359708 @default.
• W2003235575 cites W2096222053 @default.
• W2003235575 cites W2105550070 @default.
• W2003235575 cites W2106488751 @default.
• W2003235575 cites W2117305486 @default.
• W2003235575 cites W2117703098 @default.
• W2003235575 cites W2119524641 @default.
• W2003235575 cites W2124600242 @default.
• W2003235575 cites W2126299527 @default.
• W2003235575 cites W2129061795 @default.
• W2003235575 cites W2136422355 @default.
• W2003235575 cites W2138538568 @default.
• W2003235575 cites W2138741390 @default.
• W2003235575 cites W2139704528 @default.
• W2003235575 cites W2139821729 @default.
• W2003235575 cites W2143422704 @default.
• W2003235575 cites W2153108053 @default.
• W2003235575 cites W2155430431 @default.
• W2003235575 cites W2156766604 @default.
• W2003235575 cites W2164562866 @default.
• W2003235575 cites W2165526268 @default.
• W2003235575 cites W2170904543 @default.
• W2003235575 cites W2404639217 @default.
• W2003235575 cites W4244107785 @default.
• W2003235575 cites W4252721990 @default.
• W2003235575 cites W4296396329 @default.
• W2003235575 doi "https://doi.org/10.1111/j.1399-5618.2005.00211.x" @default.
• W2003235575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15948763" @default.
• W2003235575 hasPublicationYear "2005" @default.
• W2003235575 type Work @default.
• W2003235575 sameAs 2003235575 @default.
• W2003235575 citedByCount "11" @default.
• W2003235575 crossrefType "journal-article" @default.
• W2003235575 hasAuthorship W2003235575A5035147009 @default.
• W2003235575 hasConcept C118552586 @default.
• W2003235575 hasConcept C120069818 @default.
• W2003235575 hasConcept C15744967 @default.
• W2003235575 hasConcept C169760540 @default.
• W2003235575 hasConcept C169900460 @default.
• W2003235575 hasConcept C199596767 @default.
• W2003235575 hasConcept C2776174506 @default.
• W2003235575 hasConcept C2776412080 @default.
• W2003235575 hasConcept C2776809841 @default.
• W2003235575 hasConcept C2780051608 @default.
• W2003235575 hasConcept C2781246090 @default.
• W2003235575 hasConcept C513476851 @default.
• W2003235575 hasConcept C58693492 @default.
• W2003235575 hasConcept C60644358 @default.
• W2003235575 hasConcept C71924100 @default.
• W2003235575 hasConcept C86803240 @default.
• W2003235575 hasConceptScore W2003235575C118552586 @default.
• W2003235575 hasConceptScore W2003235575C120069818 @default.
• W2003235575 hasConceptScore W2003235575C15744967 @default.
• W2003235575 hasConceptScore W2003235575C169760540 @default.
• W2003235575 hasConceptScore W2003235575C169900460 @default.
• W2003235575 hasConceptScore W2003235575C199596767 @default.
• W2003235575 hasConceptScore W2003235575C2776174506 @default.
• W2003235575 hasConceptScore W2003235575C2776412080 @default.
• W2003235575 hasConceptScore W2003235575C2776809841 @default.
• W2003235575 hasConceptScore W2003235575C2780051608 @default.
• W2003235575 hasConceptScore W2003235575C2781246090 @default.
• W2003235575 hasConceptScore W2003235575C513476851 @default.
• W2003235575 hasConceptScore W2003235575C58693492 @default.
• W2003235575 hasConceptScore W2003235575C60644358 @default.
• W2003235575 hasConceptScore W2003235575C71924100 @default.
• W2003235575 hasConceptScore W2003235575C86803240 @default.
• W2003235575 hasLocation W20032355751 @default.
• W2003235575 hasLocation W20032355752 @default.
• W2003235575 hasOpenAccess W2003235575 @default.
• W2003235575 hasPrimaryLocation W20032355751 @default.
• W2003235575 hasRelatedWork W1979364632 @default.
• W2003235575 hasRelatedWork W1982800167 @default.
• W2003235575 hasRelatedWork W2003235575 @default.
• W2003235575 hasRelatedWork W2003951046 @default.
• W2003235575 hasRelatedWork W2016490263 @default.
• W2003235575 hasRelatedWork W2046870662 @default.
• W2003235575 hasRelatedWork W2049673912 @default.
• W2003235575 hasRelatedWork W2255458799 @default.
• W2003235575 hasRelatedWork W2587088030 @default.
• W2003235575 hasRelatedWork W2744314163 @default.
• W2003235575 isParatext "false" @default.

• next