Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003237575> ?p ?o ?g. }
- W2003237575 endingPage "938" @default.
- W2003237575 startingPage "929" @default.
- W2003237575 abstract "Filamentous aggregates formed by α-synuclein are a prominent and presumably key etiological factor in Parkinson's and other neurodegenerative diseases characterized by motor disorders. Numerous studies have demonstrated that various environmental and intracellular factors affect the fibrillation properties of α-synuclein, e.g. by accelerating the process of assembly. Histones, the major component and constituent of chromatin, interact specifically with α-synuclein and enhance its fibrillation significantly. Here, we report that another component of chromatin, double-stranded DNA (dsDNA), either linear or supercoiled, also interacts with wild-type α-synuclein, leading to a significant stimulation of α-synuclein assembly into mature fibrils characterized by a reduced lag phase. In general, the morphology of the fibrils remains unchanged in the presence of linear dsDNA. Electron microscopy reveals that DNA forms various types of complexes upon association with the fibrils at their surface without distortion of the double-helical structure. The existence of these complexes was confirmed by the electrophoresis, which also demonstrated that a fraction of the associated DNA was resistant to digestion by restriction endonucleases. Fibrils assembled from the α-synuclein mutants A30P and A53T and the C-terminally truncated variants (encoding amino acid residues 1–108 or 1–124) also form complexes with linear dsDNA. Possible mechanisms and implications of dsDNA–α-synuclein interactions are discussed." @default.
- W2003237575 created "2016-06-24" @default.
- W2003237575 creator A5000854547 @default.
- W2003237575 creator A5003623266 @default.
- W2003237575 creator A5049383907 @default.
- W2003237575 creator A5068353740 @default.
- W2003237575 date "2004-12-01" @default.
- W2003237575 modified "2023-10-16" @default.
- W2003237575 title "Double-stranded DNA Stimulates the Fibrillation of α-Synuclein in vitro and is Associated with the Mature Fibrils: An Electron Microscopy Study" @default.
- W2003237575 cites W1527671059 @default.
- W2003237575 cites W1591724033 @default.
- W2003237575 cites W1720678970 @default.
- W2003237575 cites W1966130903 @default.
- W2003237575 cites W1966691229 @default.
- W2003237575 cites W1968942251 @default.
- W2003237575 cites W1973897761 @default.
- W2003237575 cites W1986196133 @default.
- W2003237575 cites W1986625112 @default.
- W2003237575 cites W1997355141 @default.
- W2003237575 cites W2000036069 @default.
- W2003237575 cites W2001407922 @default.
- W2003237575 cites W2009556855 @default.
- W2003237575 cites W2014485936 @default.
- W2003237575 cites W2015628955 @default.
- W2003237575 cites W2018633688 @default.
- W2003237575 cites W2019326808 @default.
- W2003237575 cites W2020520661 @default.
- W2003237575 cites W2021977313 @default.
- W2003237575 cites W2022794788 @default.
- W2003237575 cites W2024141588 @default.
- W2003237575 cites W2028652101 @default.
- W2003237575 cites W2031982078 @default.
- W2003237575 cites W2032392617 @default.
- W2003237575 cites W2033829612 @default.
- W2003237575 cites W2034798093 @default.
- W2003237575 cites W2038729585 @default.
- W2003237575 cites W2040351396 @default.
- W2003237575 cites W2046014998 @default.
- W2003237575 cites W2052606462 @default.
- W2003237575 cites W2055255898 @default.
- W2003237575 cites W2060745831 @default.
- W2003237575 cites W2064080881 @default.
- W2003237575 cites W2071574236 @default.
- W2003237575 cites W2072249047 @default.
- W2003237575 cites W2072998862 @default.
- W2003237575 cites W2074180389 @default.
- W2003237575 cites W2074649216 @default.
- W2003237575 cites W2077044335 @default.
- W2003237575 cites W2078920306 @default.
- W2003237575 cites W2082790220 @default.
- W2003237575 cites W2089386161 @default.
- W2003237575 cites W2089735758 @default.
- W2003237575 cites W2091265794 @default.
- W2003237575 cites W2095851154 @default.
- W2003237575 cites W2096425372 @default.
- W2003237575 cites W2097965815 @default.
- W2003237575 cites W2119693327 @default.
- W2003237575 cites W2130352925 @default.
- W2003237575 cites W2133272695 @default.
- W2003237575 cites W2149472608 @default.
- W2003237575 cites W2150656456 @default.
- W2003237575 cites W2154721456 @default.
- W2003237575 cites W2168970921 @default.
- W2003237575 cites W4210968583 @default.
- W2003237575 doi "https://doi.org/10.1016/j.jmb.2004.09.096" @default.
- W2003237575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15544803" @default.
- W2003237575 hasPublicationYear "2004" @default.
- W2003237575 type Work @default.
- W2003237575 sameAs 2003237575 @default.
- W2003237575 citedByCount "68" @default.
- W2003237575 countsByYear W20032375752012 @default.
- W2003237575 countsByYear W20032375752013 @default.
- W2003237575 countsByYear W20032375752014 @default.
- W2003237575 countsByYear W20032375752015 @default.
- W2003237575 countsByYear W20032375752016 @default.
- W2003237575 countsByYear W20032375752017 @default.
- W2003237575 countsByYear W20032375752018 @default.
- W2003237575 countsByYear W20032375752019 @default.
- W2003237575 countsByYear W20032375752020 @default.
- W2003237575 countsByYear W20032375752021 @default.
- W2003237575 countsByYear W20032375752022 @default.
- W2003237575 countsByYear W20032375752023 @default.
- W2003237575 crossrefType "journal-article" @default.
- W2003237575 hasAuthorship W2003237575A5000854547 @default.
- W2003237575 hasAuthorship W2003237575A5003623266 @default.
- W2003237575 hasAuthorship W2003237575A5049383907 @default.
- W2003237575 hasAuthorship W2003237575A5068353740 @default.
- W2003237575 hasBestOaLocation W20032375752 @default.
- W2003237575 hasConcept C104317684 @default.
- W2003237575 hasConcept C12554922 @default.
- W2003237575 hasConcept C143065580 @default.
- W2003237575 hasConcept C185592680 @default.
- W2003237575 hasConcept C27523624 @default.
- W2003237575 hasConcept C552990157 @default.
- W2003237575 hasConcept C55493867 @default.
- W2003237575 hasConcept C83640560 @default.
- W2003237575 hasConcept C86803240 @default.
- W2003237575 hasConcept C95444343 @default.