Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003237992> ?p ?o ?g. }
- W2003237992 endingPage "564" @default.
- W2003237992 startingPage "552" @default.
- W2003237992 abstract "During the past decade, it has become clear that the mammalian liver contains stem/progenitor cells. These cells are derived embryologically from the foregut endoderm (see schematic diagram, Fig. 4) and seed the bone marrow, giving rise to hematopoietic stem cells. They also generate undifferentiated epithelial cells which are maintained in the canals of Hering, situated at the terminal webs of the bile ductules. Both hematopoietic stem cells and canals of Hering cells can give rise to hepatic ‘oval cells’, which can differentiate into hepatocytes and bile duct epithelial cells and are thus considered stem/progenitor cells. A role for stem/progenitor cells in maintaining the liver parenchyma during normal liver cell turnover or in restoring liver mass during liver regeneration has not been established. However, these cells can be induced to proliferate under circumstances in which the proliferative capacity of mature hepatocytes is blocked. Both hepatocytes and stem/progenitor cells can repopulate the liver under highly selective conditions of severe continuous liver injury or disruption of endogenous hepatocytes proliferation, but only stem/progenitor cells can do this in a normal liver environment. Recently, it has been discovered that hematopoietic stem cells can migrate to the liver and differentiate into hepatocytes in both rodent models and in humans; however, a role for these cells in liver regeneration or repopulation remains to be established. All of these findings provide hope that under selected circumstances cell transplantation will become a therapeutic reality in the treatment of inherited or acquired chronic liver diseases." @default.
- W2003237992 created "2016-06-24" @default.
- W2003237992 creator A5056845252 @default.
- W2003237992 creator A5087066859 @default.
- W2003237992 date "2002-04-01" @default.
- W2003237992 modified "2023-09-25" @default.
- W2003237992 title "Liver stem cells and model systems for liver repopulation" @default.
- W2003237992 cites W126539919 @default.
- W2003237992 cites W1514351476 @default.
- W2003237992 cites W1535549793 @default.
- W2003237992 cites W1542326554 @default.
- W2003237992 cites W1571853300 @default.
- W2003237992 cites W1839696315 @default.
- W2003237992 cites W1867279571 @default.
- W2003237992 cites W1908301178 @default.
- W2003237992 cites W1964720896 @default.
- W2003237992 cites W1967703106 @default.
- W2003237992 cites W1970895440 @default.
- W2003237992 cites W1972487225 @default.
- W2003237992 cites W1973657908 @default.
- W2003237992 cites W1975655671 @default.
- W2003237992 cites W1976183817 @default.
- W2003237992 cites W1978880070 @default.
- W2003237992 cites W1980584105 @default.
- W2003237992 cites W1982022033 @default.
- W2003237992 cites W1982635432 @default.
- W2003237992 cites W1985649928 @default.
- W2003237992 cites W1986826310 @default.
- W2003237992 cites W1987402927 @default.
- W2003237992 cites W1991501430 @default.
- W2003237992 cites W1991586953 @default.
- W2003237992 cites W1992201379 @default.
- W2003237992 cites W1992396018 @default.
- W2003237992 cites W1995026118 @default.
- W2003237992 cites W1995612506 @default.
- W2003237992 cites W1996109421 @default.
- W2003237992 cites W1999197639 @default.
- W2003237992 cites W2000101394 @default.
- W2003237992 cites W2001675896 @default.
- W2003237992 cites W2008380707 @default.
- W2003237992 cites W2012604405 @default.
- W2003237992 cites W2014695762 @default.
- W2003237992 cites W2017200989 @default.
- W2003237992 cites W2017404742 @default.
- W2003237992 cites W2017953073 @default.
- W2003237992 cites W2019477145 @default.
- W2003237992 cites W2019936892 @default.
- W2003237992 cites W2021878044 @default.
- W2003237992 cites W2031521660 @default.
- W2003237992 cites W2033791639 @default.
- W2003237992 cites W2035722478 @default.
- W2003237992 cites W2044648356 @default.
- W2003237992 cites W2045762602 @default.
- W2003237992 cites W2049318896 @default.
- W2003237992 cites W2051172626 @default.
- W2003237992 cites W2052366680 @default.
- W2003237992 cites W2054121629 @default.
- W2003237992 cites W2054556504 @default.
- W2003237992 cites W2055071452 @default.
- W2003237992 cites W2065412622 @default.
- W2003237992 cites W2068764558 @default.
- W2003237992 cites W2070777203 @default.
- W2003237992 cites W2073808856 @default.
- W2003237992 cites W2074070905 @default.
- W2003237992 cites W2075532352 @default.
- W2003237992 cites W2075573504 @default.
- W2003237992 cites W2081631539 @default.
- W2003237992 cites W2081898172 @default.
- W2003237992 cites W2082344386 @default.
- W2003237992 cites W2083581104 @default.
- W2003237992 cites W2083928202 @default.
- W2003237992 cites W2084508917 @default.
- W2003237992 cites W2084936584 @default.
- W2003237992 cites W2086943348 @default.
- W2003237992 cites W2089282501 @default.
- W2003237992 cites W2089582480 @default.
- W2003237992 cites W2090288308 @default.
- W2003237992 cites W2093634017 @default.
- W2003237992 cites W2098015360 @default.
- W2003237992 cites W2109971285 @default.
- W2003237992 cites W2110649813 @default.
- W2003237992 cites W2115772492 @default.
- W2003237992 cites W2118365585 @default.
- W2003237992 cites W2118834966 @default.
- W2003237992 cites W2121850637 @default.
- W2003237992 cites W2122185025 @default.
- W2003237992 cites W2134955682 @default.
- W2003237992 cites W2135852096 @default.
- W2003237992 cites W2139432060 @default.
- W2003237992 cites W2142895121 @default.
- W2003237992 cites W2144715892 @default.
- W2003237992 cites W2148459495 @default.
- W2003237992 cites W2152429894 @default.
- W2003237992 cites W2315457571 @default.
- W2003237992 cites W2322839894 @default.
- W2003237992 cites W2331630900 @default.
- W2003237992 cites W2770334239 @default.
- W2003237992 cites W4211173486 @default.