Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003238220> ?p ?o ?g. }
- W2003238220 endingPage "101" @default.
- W2003238220 startingPage "87" @default.
- W2003238220 abstract "The need to eliminate autoreactive B cells must be checked against the need for a diverse B-cell repertoire. Protein tyrosine phosphatases SHP1 and CD45 act antagonistically within B cells to set the threshold level of antigen-receptor engagement required for B-cell elimination. The fate of B cells binding weak autoantigens is also regulated by interclonal competition. In the presence of a normal diverse repertoire of competitor B cells, the autoantigen-binding cells are excluded from follicles in spleen and lymph nodes and undergo rapid cell death. In the absence of interclonal competition, the autoreactive cells enter the follicular microenvironment and survive. A model in which B cells compete for access to limiting follicular niches in order to survive is discussed." @default.
- W2003238220 created "2016-06-24" @default.
- W2003238220 creator A5061559047 @default.
- W2003238220 date "1997-04-01" @default.
- W2003238220 modified "2023-10-13" @default.
- W2003238220 title "Signaling thresholds and interclonal competition in preimmune B-cell selection" @default.
- W2003238220 cites W1489752929 @default.
- W2003238220 cites W1493244741 @default.
- W2003238220 cites W1496165222 @default.
- W2003238220 cites W1522382197 @default.
- W2003238220 cites W1545458002 @default.
- W2003238220 cites W1571932373 @default.
- W2003238220 cites W1585570459 @default.
- W2003238220 cites W1624366049 @default.
- W2003238220 cites W1664246182 @default.
- W2003238220 cites W16734497 @default.
- W2003238220 cites W1705381357 @default.
- W2003238220 cites W1790227735 @default.
- W2003238220 cites W1810839417 @default.
- W2003238220 cites W1852634555 @default.
- W2003238220 cites W1897846269 @default.
- W2003238220 cites W1964764518 @default.
- W2003238220 cites W1964895771 @default.
- W2003238220 cites W1966657425 @default.
- W2003238220 cites W1966949480 @default.
- W2003238220 cites W1968757041 @default.
- W2003238220 cites W1969397646 @default.
- W2003238220 cites W1970762550 @default.
- W2003238220 cites W1975142943 @default.
- W2003238220 cites W1975654480 @default.
- W2003238220 cites W1976805459 @default.
- W2003238220 cites W1977158130 @default.
- W2003238220 cites W1981525542 @default.
- W2003238220 cites W1988379927 @default.
- W2003238220 cites W1988562333 @default.
- W2003238220 cites W1989997867 @default.
- W2003238220 cites W1993948601 @default.
- W2003238220 cites W1995380127 @default.
- W2003238220 cites W1996169398 @default.
- W2003238220 cites W1996486759 @default.
- W2003238220 cites W2002972650 @default.
- W2003238220 cites W2003044215 @default.
- W2003238220 cites W2003955248 @default.
- W2003238220 cites W2005398131 @default.
- W2003238220 cites W2006363995 @default.
- W2003238220 cites W2006519779 @default.
- W2003238220 cites W2006881610 @default.
- W2003238220 cites W2007138237 @default.
- W2003238220 cites W2012818004 @default.
- W2003238220 cites W2015042072 @default.
- W2003238220 cites W2016208323 @default.
- W2003238220 cites W2016808992 @default.
- W2003238220 cites W2016913945 @default.
- W2003238220 cites W2017117257 @default.
- W2003238220 cites W2017533703 @default.
- W2003238220 cites W2018453892 @default.
- W2003238220 cites W2018826402 @default.
- W2003238220 cites W2024114633 @default.
- W2003238220 cites W2030793757 @default.
- W2003238220 cites W2034515222 @default.
- W2003238220 cites W2036859226 @default.
- W2003238220 cites W2040901050 @default.
- W2003238220 cites W2041354260 @default.
- W2003238220 cites W2042248645 @default.
- W2003238220 cites W2044485561 @default.
- W2003238220 cites W2051729351 @default.
- W2003238220 cites W2052438035 @default.
- W2003238220 cites W2059113674 @default.
- W2003238220 cites W2059761860 @default.
- W2003238220 cites W2061140050 @default.
- W2003238220 cites W2062198339 @default.
- W2003238220 cites W2063778211 @default.
- W2003238220 cites W2063825367 @default.
- W2003238220 cites W2067247571 @default.
- W2003238220 cites W2069679620 @default.
- W2003238220 cites W2071883654 @default.
- W2003238220 cites W2077286167 @default.
- W2003238220 cites W2078702573 @default.
- W2003238220 cites W208343037 @default.
- W2003238220 cites W2086209569 @default.
- W2003238220 cites W2090704440 @default.
- W2003238220 cites W2091986547 @default.
- W2003238220 cites W2094940251 @default.
- W2003238220 cites W2095516695 @default.
- W2003238220 cites W2095903025 @default.
- W2003238220 cites W2098497060 @default.
- W2003238220 cites W2098997742 @default.
- W2003238220 cites W2099675490 @default.
- W2003238220 cites W2100869656 @default.
- W2003238220 cites W2101187881 @default.
- W2003238220 cites W2102829292 @default.
- W2003238220 cites W2102910430 @default.
- W2003238220 cites W2104174478 @default.
- W2003238220 cites W2106417331 @default.
- W2003238220 cites W2107104928 @default.
- W2003238220 cites W2107335407 @default.
- W2003238220 cites W2114411910 @default.
- W2003238220 cites W2121070193 @default.