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- W2003239817 abstract "To establish whether cytokine release is implicated in thyroid hormone changes during surgical stress we studied 36 adult patients (20 men; mean age ± SD: 68.5 ± 10.5 years) undergoing elective major abdominal operations. We measured tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8 and IL-10 and thyrotropin (TSH), free thyroxine (FT<sub>4</sub>) and triiodothyronine (T<sub>3</sub>) before scheduled non-emergency surgery, immediately postoperatively, on the 1st postoperative day (post-1) and on the 2nd postoperative day (post-2). TNF-α, IL-6 and IL-8 peaked on day post-1 whereas IL-10 peaked immediately postoperatively. Fourteen of 36 patients had low T<sub>3</sub> levels after surgery, indicating non-thyroidal illness (NTI). Significant negative correlations were noted among TNF-α, IL-6 and IL-8 against T<sub>3</sub> and FT<sub>4</sub>. Cytokines are responsible, at least in part, for NTI following major operations." @default.
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- W2003239817 date "2007-01-01" @default.
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- W2003239817 title "Thyroid Function Changes and Cytokine Alterations following Major Surgery" @default.
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- W2003239817 doi "https://doi.org/10.1159/000112049" @default.
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