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• W2003240557 abstract "To investigate the effect of a macrolide antibiotic, azithromycin, on the molecular organization of DPPC:DOPC, DPPE:DOPC, SM:DOPC, and SM:Chol:DOPC lipid vesicles as well as the effect of azithromycin on membrane fluidity and permeability.The molecular organization of model membranes was characterized by atomic force microscopy (AFM), and the amount of azithromycin bound to lipid membranes was determined by equilibrium dialysis. The membrane fluidity and permeability were analyzed using fluorescence polarization studies and release of calcein-entrapped liposomes, respectively.In situ AFM images revealed that azithromycin leads to the erosion and disappearance of DPPC and DPPE gel domains, whereas no effect was noted on SM and SM:cholesterol domains. Although azithromycin did not alter the permeability of DPPC:DOPC, DPPE:DOPC, SM:DOPC, and SM:Chol:DOPC lipid vesicles, it increased the fluidity at the hydrophilic/hydrophobic interface in DPPC:DOPC and DPPE:DOPC models. This effect may be responsible for the ability of azithromycin to erode the DPPC and DPPE gel domains, as observed by AFM.This study shows the interest of both AFM and biophysical methods to characterize the drug-membrane interactions." @default.
• W2003240557 created "2016-06-24" @default.
• W2003240557 creator A5033267263 @default.
• W2003240557 creator A5060079116 @default.
• W2003240557 creator A5066628190 @default.
• W2003240557 creator A5083028571 @default.
• W2003240557 date "2005-03-01" @default.
• W2003240557 modified "2023-10-06" @default.
• W2003240557 title "Interaction of the Macrolide Antibiotic Azithromycin with Lipid Bilayers: Effect on Membrane Organization, Fluidity, and Permeability" @default.
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• W2003240557 doi "https://doi.org/10.1007/s11095-004-1885-8" @default.
• W2003240557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15835753" @default.
• W2003240557 hasPublicationYear "2005" @default.
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