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- W2003240972 abstract "Abstract The possible mechanism of action of the progesterone-releasing intrauterine device has been studied by means of determination of the action that uterine washings have on the metabolism and capacitation of human and rabbit spermatozoa. Uterine washings from normal, untreated women, induce, in human spermatozoa, the same changes although of lesser magnitude, that have been previously reported as possibly participating in the uterine stage of capacitation. Uterine washings obtained from progesterone-T wearing women produce a significant decrease in oxygen uptake and glucose utilization, an inhibition of the BANA-hydrolytic activity, and changes in the tetracycline binding and release processes. All these changes support the hypothesis that at least part of the mechanism of action of the progesterone-releasing type of intrauterine devices is due to a direct capacitation inhibiting effect of the uterine secretion. This hypothesis is strengthened by the direct demonstration of inhibition of in vitro rabbit spermatozoa capacitation produced by these washings." @default.
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- W2003240972 date "1974-01-01" @default.
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- W2003240972 title "Intrauterine contraception with the progesterone-T device" @default.
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- W2003240972 doi "https://doi.org/10.1016/0010-7824(74)90093-6" @default.
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