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- W2003241018 abstract "Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a transcriptional repressor, K-bZIP. We previously demonstrated that K-bZIP suppresses interferon (IFN)-β expression. Here, we provide evidence that K-bZIP affects IFN signaling, resulting in impaired IFN-stimulated genes expression. Inhibition by K-bZIP is independent of the phosphorylation of signal transducers and activators of transcription proteins or the binding of the IFN-stimulated gene factor 3 to the IFN-stimulated responsive element. Relative to the wild-type protein, K-bZIPK158R mutant exhibited reduced inhibitory activity, indicating that sumoylation on K158 is likely important for this effect. A new sumoylation site present within a newly identified K-bZIP variant and absent from the fully spliced K-bZIP was also identified. Furthermore, K-bZIP is acetylated on lysine residues and CBP enhances K-bZIP acetylation. Combined with its ability to negatively modulate IFN-β production and inhibit type I IFN signaling, K-bZIP represents a viral immunomodulator that contributes to curtail immune defense mechanisms and favor KSHV's persistence." @default.
- W2003241018 created "2016-06-24" @default.
- W2003241018 creator A5022819003 @default.
- W2003241018 creator A5065583443 @default.
- W2003241018 creator A5085458000 @default.
- W2003241018 date "2010-12-01" @default.
- W2003241018 modified "2023-09-25" @default.
- W2003241018 title "Repression of interferon-α stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein" @default.
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- W2003241018 doi "https://doi.org/10.1016/j.virol.2010.07.027" @default.
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