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- W2003241548 abstract "The eukaryotic mRNA 5' cap structure facilitates translation. However, cap-dependent translation is impaired at mitosis, suggesting a cap-independent mechanism for mRNAs translated during mitosis. Translation of ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines, peaks twice during the cell cycle, at the G1/S transition and at G2/M. Here, we describe a cap-independent internal ribosome entry site (IRES) in the ODC mRNA that functions exclusively at G2/M. This ensures elevated levels of polyamines, which are implicated in mitotic spindle formation and chromatin condensation. c-myc mRNA also contains an IRES that functions during mitosis. Thus, IRES-dependent translation is likely to be a general mechanism to synthesize short-lived proteins even at mitosis, when cap-dependent translation is interdicted." @default.
- W2003241548 created "2016-06-24" @default.
- W2003241548 creator A5019957951 @default.
- W2003241548 creator A5039575338 @default.
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- W2003241548 date "2000-04-01" @default.
- W2003241548 modified "2023-10-16" @default.
- W2003241548 title "A Cell Cycle–Dependent Internal Ribosome Entry Site" @default.
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- W2003241548 doi "https://doi.org/10.1016/s1097-2765(00)80240-3" @default.
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