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• W2003242290 abstract "Biotransformations of steroid compounds: androstenedione, testosterone, progesterone, pregnenolone and DHEA using Chaetomium sp. 1 KCH 6651 strain as a biocatalyst were investigated. The microorganism proved capable of selective hydroxylation of the steroid substrates. Androstenedione was converted to 14alpha-hydroxyandrost-4-en-3,17-dione (in over 75% yield) and 6beta-hydroxyandrost-4-en-3,17-dione (in low yield), while testosterone underwent regioselective hydroxylation at 6beta position. Progesterone was transformed to a single product-6beta,14alpha-dihydroxypregnan-4-en-3,20-dione in high yield, whereas biotransformation of DHEA resulted in the formation of 7alpha-hydroxy derivative, which was subsequently converted to 7alpha-hydroxyandrost-4-en-3,17-dione." @default.
• W2003242290 created "2016-06-24" @default.
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• W2003242290 date "2009-08-01" @default.
• W2003242290 modified "2023-10-16" @default.
• W2003242290 title "Biotransformations of steroid compounds by Chaetomium sp. KCH 6651" @default.
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• W2003242290 doi "https://doi.org/10.1016/j.steroids.2009.02.006" @default.
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