FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003244012> ?p ?o ?g. }

• W2003244012 endingPage "e3359" @default.
• W2003244012 startingPage "e3359" @default.
• W2003244012 abstract "SurA is a periplasmic peptidyl-prolyl isomerase (PPIase) and chaperone of Escherichia coli and other Gram-negative bacteria. In contrast to other PPIases, SurA appears to have a distinct role in chaperoning newly synthesized porins destined for insertion into the outer membrane. Previous studies have indicated that the chaperone activity of SurA rests in its core module (the N- plus C-terminal domains), based on in vivo envelope phenotypes and in vitro binding and protection of non-native substrates.In this study, we determined the components of SurA required for chaperone activity using in vivo phenotypes relevant to disease causation by uropathogenic E. coli (UPEC), namely membrane resistance to permeation by antimicrobials and maturation of the type 1 pilus usher FimD. FimD is a SurA-dependent, integral outer membrane protein through which heteropolymeric type 1 pili, which confer bladder epithelial binding and invasion capacity upon uropathogenic E. coli, are assembled and extruded. Consistent with prior results, the in vivo chaperone activity of SurA in UPEC rested primarily in the core module. However, the PPIase domains I and II were not expendable for wild-type resistance to novobiocin in broth culture. Steady-state levels of FimD were substantially restored in the UPEC surA mutant complemented with the SurA N- plus C-terminal domains. The addition of PPIase domain I augmented FimD maturation into the outer membrane, consistent with a model in which domain I enhances stability of and/or substrate binding by the core module.Our results confirm the core module of E. coli SurA as a potential target for novel anti-infective development." @default.
• W2003244012 created "2016-06-24" @default.
• W2003244012 creator A5022653312 @default.
• W2003244012 creator A5060631051 @default.
• W2003244012 date "2008-10-06" @default.
• W2003244012 modified "2023-10-06" @default.
• W2003244012 title "Components of SurA Required for Outer Membrane Biogenesis in Uropathogenic Escherichia coli" @default.
• W2003244012 cites W1754378627 @default.
• W2003244012 cites W1944838415 @default.
• W2003244012 cites W1977190262 @default.
• W2003244012 cites W1978413629 @default.
• W2003244012 cites W1983314769 @default.
• W2003244012 cites W1987774012 @default.
• W2003244012 cites W1990279175 @default.
• W2003244012 cites W1990365720 @default.
• W2003244012 cites W1993077659 @default.
• W2003244012 cites W2019875425 @default.
• W2003244012 cites W2043485198 @default.
• W2003244012 cites W2044784863 @default.
• W2003244012 cites W2046177551 @default.
• W2003244012 cites W2046721427 @default.
• W2003244012 cites W2050869281 @default.
• W2003244012 cites W2056406408 @default.
• W2003244012 cites W2065931405 @default.
• W2003244012 cites W2079472529 @default.
• W2003244012 cites W2081717721 @default.
• W2003244012 cites W2090919148 @default.
• W2003244012 cites W2107920637 @default.
• W2003244012 cites W2114511757 @default.
• W2003244012 cites W2124519865 @default.
• W2003244012 cites W2125743541 @default.
• W2003244012 cites W2151645494 @default.
• W2003244012 cites W2153435059 @default.
• W2003244012 cites W2153932901 @default.
• W2003244012 cites W2158714788 @default.
• W2003244012 cites W2164023475 @default.
• W2003244012 cites W2171809976 @default.
• W2003244012 cites W31581040 @default.
• W2003244012 doi "https://doi.org/10.1371/journal.pone.0003359" @default.
• W2003244012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2556385" @default.
• W2003244012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18836534" @default.
• W2003244012 hasPublicationYear "2008" @default.
• W2003244012 type Work @default.
• W2003244012 sameAs 2003244012 @default.
• W2003244012 citedByCount "33" @default.
• W2003244012 countsByYear W20032440122012 @default.
• W2003244012 countsByYear W20032440122013 @default.
• W2003244012 countsByYear W20032440122014 @default.
• W2003244012 countsByYear W20032440122015 @default.
• W2003244012 countsByYear W20032440122016 @default.
• W2003244012 countsByYear W20032440122018 @default.
• W2003244012 countsByYear W20032440122019 @default.
• W2003244012 countsByYear W20032440122020 @default.
• W2003244012 countsByYear W20032440122022 @default.
• W2003244012 crossrefType "journal-article" @default.
• W2003244012 hasAuthorship W2003244012A5022653312 @default.
• W2003244012 hasAuthorship W2003244012A5060631051 @default.
• W2003244012 hasBestOaLocation W20032440121 @default.
• W2003244012 hasConcept C104317684 @default.
• W2003244012 hasConcept C131934819 @default.
• W2003244012 hasConcept C142724271 @default.
• W2003244012 hasConcept C143065580 @default.
• W2003244012 hasConcept C146587185 @default.
• W2003244012 hasConcept C154472170 @default.
• W2003244012 hasConcept C174832134 @default.
• W2003244012 hasConcept C181199279 @default.
• W2003244012 hasConcept C201663137 @default.
• W2003244012 hasConcept C2775962898 @default.
• W2003244012 hasConcept C2781098309 @default.
• W2003244012 hasConcept C2781264208 @default.
• W2003244012 hasConcept C2910677434 @default.
• W2003244012 hasConcept C547475151 @default.
• W2003244012 hasConcept C55493867 @default.
• W2003244012 hasConcept C71924100 @default.
• W2003244012 hasConcept C86803240 @default.
• W2003244012 hasConcept C89423630 @default.
• W2003244012 hasConcept C95444343 @default.
• W2003244012 hasConceptScore W2003244012C104317684 @default.
• W2003244012 hasConceptScore W2003244012C131934819 @default.
• W2003244012 hasConceptScore W2003244012C142724271 @default.
• W2003244012 hasConceptScore W2003244012C143065580 @default.
• W2003244012 hasConceptScore W2003244012C146587185 @default.
• W2003244012 hasConceptScore W2003244012C154472170 @default.
• W2003244012 hasConceptScore W2003244012C174832134 @default.
• W2003244012 hasConceptScore W2003244012C181199279 @default.
• W2003244012 hasConceptScore W2003244012C201663137 @default.
• W2003244012 hasConceptScore W2003244012C2775962898 @default.
• W2003244012 hasConceptScore W2003244012C2781098309 @default.
• W2003244012 hasConceptScore W2003244012C2781264208 @default.
• W2003244012 hasConceptScore W2003244012C2910677434 @default.
• W2003244012 hasConceptScore W2003244012C547475151 @default.
• W2003244012 hasConceptScore W2003244012C55493867 @default.
• W2003244012 hasConceptScore W2003244012C71924100 @default.
• W2003244012 hasConceptScore W2003244012C86803240 @default.
• W2003244012 hasConceptScore W2003244012C89423630 @default.
• W2003244012 hasConceptScore W2003244012C95444343 @default.
• W2003244012 hasIssue "10" @default.
• W2003244012 hasLocation W20032440121 @default.

• next