Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003246987> ?p ?o ?g. }
- W2003246987 endingPage "40" @default.
- W2003246987 startingPage "31" @default.
- W2003246987 abstract "The serum amyloid A activating factor (SAF) was identified as a family of inducible transcription factors that is activated by many mediators of inflammation. Its activation involves a phosphorylation event, whose mechanism is not fully understood. Here, we show that cAMP treatment of several cell types, including mouse liver-derived BNL CL.2, human monocyte-derived THP-1, and a primary culture of vascular smooth muscle cells from porcine aorta, activated cellular SAF's ability to bind DNA. The protein kinase A (PKA) activity in cytoplasmic extracts of cAMP-treated cells was responsible for the potentiation of the DNA-binding activity of the cellular SAF proteins. Furthermore, treatment of nuclear extracts of untreated cells with purified PKA increased the DNA-binding activity of cellular SAF proteins, and specific inhibitors of PKA abrogated the enhanced DNA-binding ability of SAF in the cAMP-treated cells. Consistent with these findings, overexpression of the catalytic subunit of PKA markedly increased expression of the SAF-regulated promoter. These results imply a functional role for the previously detected protein-protein interaction between SAF-1 transcription factor and the catalytic subunit of PKA and further demonstrate the consequences of cAMP-mediated signaling for the expression of SAF-regulated genes." @default.
- W2003246987 created "2016-06-24" @default.
- W2003246987 creator A5020111511 @default.
- W2003246987 creator A5022655864 @default.
- W2003246987 creator A5023928408 @default.
- W2003246987 date "2002-01-01" @default.
- W2003246987 modified "2023-09-24" @default.
- W2003246987 title "Promoter-Binding Activity of Inflammation-Responsive Transcription Factor SAF is Regulated by Cyclic AMP Signaling Pathway" @default.
- W2003246987 cites W1485104973 @default.
- W2003246987 cites W1492594459 @default.
- W2003246987 cites W1512288014 @default.
- W2003246987 cites W1512960324 @default.
- W2003246987 cites W1520052348 @default.
- W2003246987 cites W1557956840 @default.
- W2003246987 cites W1760775102 @default.
- W2003246987 cites W1906297566 @default.
- W2003246987 cites W1965372133 @default.
- W2003246987 cites W1967578063 @default.
- W2003246987 cites W1969994632 @default.
- W2003246987 cites W1970862733 @default.
- W2003246987 cites W1973135307 @default.
- W2003246987 cites W1973519389 @default.
- W2003246987 cites W1977344247 @default.
- W2003246987 cites W1979394236 @default.
- W2003246987 cites W1980195431 @default.
- W2003246987 cites W1980946495 @default.
- W2003246987 cites W1982598173 @default.
- W2003246987 cites W1983372510 @default.
- W2003246987 cites W1987000956 @default.
- W2003246987 cites W1987846388 @default.
- W2003246987 cites W1991161387 @default.
- W2003246987 cites W1993955887 @default.
- W2003246987 cites W2000011436 @default.
- W2003246987 cites W2000024512 @default.
- W2003246987 cites W2001585719 @default.
- W2003246987 cites W2004626037 @default.
- W2003246987 cites W2006470470 @default.
- W2003246987 cites W2009291798 @default.
- W2003246987 cites W2022979064 @default.
- W2003246987 cites W2026216572 @default.
- W2003246987 cites W2028242823 @default.
- W2003246987 cites W2031588343 @default.
- W2003246987 cites W2035690299 @default.
- W2003246987 cites W2037463093 @default.
- W2003246987 cites W2042040883 @default.
- W2003246987 cites W2046990960 @default.
- W2003246987 cites W2048056998 @default.
- W2003246987 cites W2048922505 @default.
- W2003246987 cites W2061484837 @default.
- W2003246987 cites W2067768430 @default.
- W2003246987 cites W2073646238 @default.
- W2003246987 cites W2093530104 @default.
- W2003246987 cites W2095860222 @default.
- W2003246987 cites W2101882577 @default.
- W2003246987 cites W2102039858 @default.
- W2003246987 cites W2110146202 @default.
- W2003246987 cites W2112543878 @default.
- W2003246987 cites W2113311538 @default.
- W2003246987 cites W2117356113 @default.
- W2003246987 cites W2128635872 @default.
- W2003246987 cites W2129447586 @default.
- W2003246987 cites W2133290360 @default.
- W2003246987 cites W2140963908 @default.
- W2003246987 cites W2141524439 @default.
- W2003246987 cites W2150746117 @default.
- W2003246987 cites W2155061900 @default.
- W2003246987 cites W2163685751 @default.
- W2003246987 cites W2244482824 @default.
- W2003246987 cites W2443456588 @default.
- W2003246987 doi "https://doi.org/10.1089/10445490252810294" @default.
- W2003246987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11879578" @default.
- W2003246987 hasPublicationYear "2002" @default.
- W2003246987 type Work @default.
- W2003246987 sameAs 2003246987 @default.
- W2003246987 citedByCount "7" @default.
- W2003246987 countsByYear W20032469872013 @default.
- W2003246987 countsByYear W20032469872018 @default.
- W2003246987 countsByYear W20032469872021 @default.
- W2003246987 crossrefType "journal-article" @default.
- W2003246987 hasAuthorship W2003246987A5020111511 @default.
- W2003246987 hasAuthorship W2003246987A5022655864 @default.
- W2003246987 hasAuthorship W2003246987A5023928408 @default.
- W2003246987 hasConcept C104292427 @default.
- W2003246987 hasConcept C104317684 @default.
- W2003246987 hasConcept C11960822 @default.
- W2003246987 hasConcept C138885662 @default.
- W2003246987 hasConcept C153911025 @default.
- W2003246987 hasConcept C1629964 @default.
- W2003246987 hasConcept C179926584 @default.
- W2003246987 hasConcept C190062978 @default.
- W2003246987 hasConcept C199172495 @default.
- W2003246987 hasConcept C203014093 @default.
- W2003246987 hasConcept C2776914184 @default.
- W2003246987 hasConcept C41895202 @default.
- W2003246987 hasConcept C55493867 @default.
- W2003246987 hasConcept C62478195 @default.
- W2003246987 hasConcept C86339819 @default.
- W2003246987 hasConcept C86803240 @default.