FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003248626> ?p ?o ?g. }

• W2003248626 endingPage "330" @default.
• W2003248626 startingPage "321" @default.
• W2003248626 abstract "Phagocytosis of naturally dying cells usually blocks inflammatory reactions in host cells. We have recently observed that clearance of cells dying through autophagy leads to a pro-inflammatory response in human macrophages. Investigating this response further, we found that during engulfment of MCF-7 or 293T cells undergoing autophagic death, but not apoptotic or anoikic ones, caspase-1 was activated and IL-1β was processed, then secreted in a MyD88-independent manner. Autophagic dying cells were capable of preventing some LPS-induced pro-inflammatory responses, such as TNFα, IL-6 and IL-8 induction, but synergized with LPS for IL-1β production. Caspase-1 inhibition prevented macrophage IL-1β release triggered by the dying cells and also other pro-inflammatory cytokines which were not formed in the presence of IL-1 receptor antagonist anakinra either. IL-1β secretion was also observed using calreticulin knock down or necrostatin treated autophagic MCF-7 cells and it required phagocytosis of the dying cells which led to ATP secretion from macrophages. Blocking K (+) efflux during phagocytosis, the presence of apyrase, adding an antagonist of the P2X7 receptor or silencing the NOD-like receptor protein NALP3 inhibited IL-1β secretion. These data suggest that during phagocytosis of autophagic dying cells ATP, acting through its receptor, initiates K (+) efflux, inflammasome activation and secretion of IL-1β, which initiates further pro-inflammatory events. Thus, autophagic death of malignant cells and their clearance may lead to immunogenic response." @default.
• W2003248626 created "2016-06-24" @default.
• W2003248626 creator A5003182212 @default.
• W2003248626 creator A5014742619 @default.
• W2003248626 creator A5025291745 @default.
• W2003248626 creator A5050360414 @default.
• W2003248626 creator A5073445040 @default.
• W2003248626 creator A5075530069 @default.
• W2003248626 creator A5091056693 @default.
• W2003248626 date "2011-03-01" @default.
• W2003248626 modified "2023-10-14" @default.
• W2003248626 title "Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1β release in human macrophages" @default.
• W2003248626 cites W1528462551 @default.
• W2003248626 cites W1529674879 @default.
• W2003248626 cites W1573103899 @default.
• W2003248626 cites W1972582451 @default.
• W2003248626 cites W1975032025 @default.
• W2003248626 cites W1977767269 @default.
• W2003248626 cites W1979526109 @default.
• W2003248626 cites W1981932438 @default.
• W2003248626 cites W1987526360 @default.
• W2003248626 cites W1987535382 @default.
• W2003248626 cites W1992789370 @default.
• W2003248626 cites W1993343884 @default.
• W2003248626 cites W2009435405 @default.
• W2003248626 cites W2016612145 @default.
• W2003248626 cites W2018607502 @default.
• W2003248626 cites W2025695096 @default.
• W2003248626 cites W2040898123 @default.
• W2003248626 cites W2060659287 @default.
• W2003248626 cites W2077353205 @default.
• W2003248626 cites W2078893058 @default.
• W2003248626 cites W2088412732 @default.
• W2003248626 cites W2091493364 @default.
• W2003248626 cites W2095537212 @default.
• W2003248626 cites W2097291203 @default.
• W2003248626 cites W2100379211 @default.
• W2003248626 cites W2114389121 @default.
• W2003248626 cites W2114769428 @default.
• W2003248626 cites W2118403357 @default.
• W2003248626 cites W2126384811 @default.
• W2003248626 cites W2130153302 @default.
• W2003248626 doi "https://doi.org/10.4161/auto.7.3.14583" @default.
• W2003248626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21217200" @default.
• W2003248626 hasPublicationYear "2011" @default.
• W2003248626 type Work @default.
• W2003248626 sameAs 2003248626 @default.
• W2003248626 citedByCount "63" @default.
• W2003248626 countsByYear W20032486262012 @default.
• W2003248626 countsByYear W20032486262013 @default.
• W2003248626 countsByYear W20032486262014 @default.
• W2003248626 countsByYear W20032486262015 @default.
• W2003248626 countsByYear W20032486262016 @default.
• W2003248626 countsByYear W20032486262017 @default.
• W2003248626 countsByYear W20032486262018 @default.
• W2003248626 countsByYear W20032486262019 @default.
• W2003248626 countsByYear W20032486262020 @default.
• W2003248626 countsByYear W20032486262021 @default.
• W2003248626 countsByYear W20032486262022 @default.
• W2003248626 countsByYear W20032486262023 @default.
• W2003248626 crossrefType "journal-article" @default.
• W2003248626 hasAuthorship W2003248626A5003182212 @default.
• W2003248626 hasAuthorship W2003248626A5014742619 @default.
• W2003248626 hasAuthorship W2003248626A5025291745 @default.
• W2003248626 hasAuthorship W2003248626A5050360414 @default.
• W2003248626 hasAuthorship W2003248626A5073445040 @default.
• W2003248626 hasAuthorship W2003248626A5075530069 @default.
• W2003248626 hasAuthorship W2003248626A5091056693 @default.
• W2003248626 hasBestOaLocation W20032486261 @default.
• W2003248626 hasConcept C160448771 @default.
• W2003248626 hasConcept C170493617 @default.
• W2003248626 hasConcept C187316574 @default.
• W2003248626 hasConcept C190283241 @default.
• W2003248626 hasConcept C202751555 @default.
• W2003248626 hasConcept C203014093 @default.
• W2003248626 hasConcept C203522944 @default.
• W2003248626 hasConcept C2776914184 @default.
• W2003248626 hasConcept C2777209026 @default.
• W2003248626 hasConcept C2778690821 @default.
• W2003248626 hasConcept C2779244956 @default.
• W2003248626 hasConcept C2779508331 @default.
• W2003248626 hasConcept C28406088 @default.
• W2003248626 hasConcept C31573885 @default.
• W2003248626 hasConcept C49039625 @default.
• W2003248626 hasConcept C55493867 @default.
• W2003248626 hasConcept C86803240 @default.
• W2003248626 hasConcept C95444343 @default.
• W2003248626 hasConceptScore W2003248626C160448771 @default.
• W2003248626 hasConceptScore W2003248626C170493617 @default.
• W2003248626 hasConceptScore W2003248626C187316574 @default.
• W2003248626 hasConceptScore W2003248626C190283241 @default.
• W2003248626 hasConceptScore W2003248626C202751555 @default.
• W2003248626 hasConceptScore W2003248626C203014093 @default.
• W2003248626 hasConceptScore W2003248626C203522944 @default.
• W2003248626 hasConceptScore W2003248626C2776914184 @default.
• W2003248626 hasConceptScore W2003248626C2777209026 @default.
• W2003248626 hasConceptScore W2003248626C2778690821 @default.
• W2003248626 hasConceptScore W2003248626C2779244956 @default.

• next