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• W2003249428 abstract "<h2>Abstract</h2> We have investigated the ovariectomy effects on the cardiovascular autonomic adaptations induced by aerobic physical training and the role played by nitric oxide (NO). Female Wistar rats (<i>n</i>=70) were divided into five groups: Sedentary Sham (SS); Trained Sham (TS); Trained Hypertensive Sham treated with <i>N</i>^G-nitro-l-arginine methyl ester (l-NAME) (THS); Trained Ovariectomized (TO); and Trained Hypertensive Ovariectomized treated with l-NAME (THO). Trained groups were submitted to a physical training during 10 weeks. The cardiovascular autonomic control was investigated in all groups using different approaches: 1) pharmacological evaluation of autonomic tonus with methylatropine and propranolol; 2) analysis of heart rate (HR) and systolic arterial pressure (AP) variability; 3) spontaneous baroreflex sensitivity (BRS) evaluation. Hypertension was observed in THS and THO groups. Pharmacological analysis showed that TS group had increased predominance of autonomic vagal tonus compared to SS group. HR and intrinsic HR were found to be reduced in all trained animals. TS group, compared to other groups, showed a reduction in LF oscillations (LF=0.2–0.75 Hz) of pulse interval in both absolute and normalized units as well as an increase in HF oscillations (HF=0.75–2.50 Hz) in normalized unit. BRS analysis showed that α-index was different between all groups. TS group presented the greatest value, followed by the TO, SS, THO and THS groups. Ovariectomy has negative effects on cardiac autonomic modulation in trained rats, which is characterized by an increase in the sympathetic autonomic modulation. These negative effects suggest NO deficiency. In contrast, the ovariectomy seems to have no effect on AP variability." @default.
• W2003249428 created "2016-06-24" @default.
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• W2003249428 date "2008-12-01" @default.
• W2003249428 modified "2023-09-27" @default.
• W2003249428 title "The effect of ovariectomy on cardiac autonomic control in rats submitted to aerobic physical training" @default.
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• W2003249428 doi "https://doi.org/10.1016/j.autneu.2008.05.003" @default.
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