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- W2003250082 abstract "Abstract Studies were performed to define mitochondrial development in relation to epithelial cell proliferation and differentiation prior to lactogenesis in the mammary gland of the mouse. Gland weight, total DNA, and total protein, selected as criteria of gland growth and proliferation, and various parameters of mitochondrial development were followed throughout the period. Gland weight and total DNA started increasing about Day 5 of pregnancy and reached maximal values by parturition. Total gland protein began to increase at the same time but did not reach maximal values until Day 4 of lactation. Total mitochondrial protein and the mitochondrial marker enzyme activities, succinate oxidase, succinate-linked ATP formation, and cytochrome oxidase increased gradually during pregnancy with rapid 2- to 3-fold increases occurring during the early days of lactation. Similarly, succinate oxidase activity per unit DNA of isolated mammary parenchymal cells increased gradually from mid-pregnancy to parturition with a precipitous, 2-fold increase occurring during early lactation. These results indicate that the major phase of mitochondrial development occurs shortly after parturition during a period subsequent to epithelial cell proliferation. This postparturient mitochondrial development may correspond primarily to a maturation of organelles formed previously during epithelial cell proliferation and not to actual replication." @default.
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- W2003250082 title "Studies of mitochondrial development prior to lactogenesis in the mouse mammary gland" @default.
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- W2003250082 doi "https://doi.org/10.1016/0003-9861(72)90428-6" @default.
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